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- W34204517 abstract "In the short time since its discovery in 1993, the prototype cyclin-dependent kinase (CDK) inhibitor p21 (CIP1, Harper et al. 1993; WAF1, El-Deiry et al. 1993; p21, Xiong et al. 1993a; CAP20, Gu et al. 1993; SDI1, Noda et al. 1994; MDA6, Jiang et al. 1995) has become an intensely studied molecule. Much has been learned about its molecular structure, biochemical interactions, and physiological role. p21 is a focal point that integrates many types of signals that impact on processes of cell division and cell death. Since 1995 to date there have been over 600 references in Current Contents dealing with WAF1 or CIP1 and they are increasing at a rate of up to 25 per week. The p53 field which dates back to 1979 has had some 6000 references on Medline since 1993. This chapter will highlight some of the recent discoveries emphasizing the role of p21 and p53 in growth control and the maintenance of genomic integrity." @default.
- W34204517 created "2016-06-24" @default.
- W34204517 creator A5075201353 @default.
- W34204517 date "1998-01-01" @default.
- W34204517 modified "2023-10-05" @default.
- W34204517 title "p21/p53, Cellular Growth Control and Genomic Integrity" @default.
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- W34204517 doi "https://doi.org/10.1007/978-3-642-71941-7_6" @default.
- W34204517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9479828" @default.
- W34204517 hasPublicationYear "1998" @default.
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