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- W342583221 abstract "Objective To investigate the relationship between IL-1B and TNF-α gene polymorphisms and susceptibilities to gastric ulcer and cancer.Methods The IL-1B-511,TNF-A-308 and TNF-A-857 gene polymorphisms of 39 patients with gastric ulcer and 35 patients with gastric cancer,both were positive for H.pylori,were analyzed by PCR-RFLP,using those of 70 healthy persons as control.Results The frequency distribution of various IL-1B-511 genotypes showed no significant difference in the patients and healthy persons.However,the frequency distribution of various TNF-A-308 and TNF-A-857 genotypes in the patients with gastric ulcer as well as that of TNF-A-308 genotypes in patients with gastric cancer showed significant difference with those in healthy persons.Logistic regression analysis showed that,compared with that in TNF-A-308 G /G carriers,the risk(OR)of gastric ulcer in TNF-A-308 A /A carriers was 21.62(95% CI:2.07 ～ 226.13);compared with that in TNF-A-857 C /C carriers,the risk(OR)of gastric ulcer in TNF-A-857 T /T carriers was 5.37(95% CI:1.28 ～ 22.50);compared with that in TNF-A-308 G /G carriers,the risk(OR)of gastric cancer in TNF-A-308 A /A was 16.41(95% CI:1.62 ～ 116.55).Conclusion TNF-α gene polymorphism was related to the susceptibilities to gastric ulcer and cancer." @default.
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- W342583221 date "2009-01-01" @default.
- W342583221 modified "2023-09-28" @default.
- W342583221 title "Relationship between IL-1B and TNF-α gene polymorphisms and susceptibilities to gastric ulcer and cancer." @default.
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