Matches in SemOpenAlex for { <https://semopenalex.org/work/W343150300> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W343150300 endingPage "1820" @default.
- W343150300 startingPage "1813" @default.
- W343150300 abstract "Abstract MiV, MiV(J.L.), and Sta glycophorins specify the respective variant phenotypes of the human MNSs blood group system. We report that unequal but homologous crossing-over between alpha and delta glycophorin genes results in three hybrid genes encoding MiV, MiV(J.L.), and Sta glycophorins. Restriction mapping and allele-specific oligonucleotide hybridization grossly defined the third intron as the probable crossing- over site and showed that MiV and MiV(J.L.) genes are arranged in the same 5′ alpha-delta 3′ frame whereas Sta gene is in a reciprocal 5′delta-alpha 3′ configuration. Genomic sequences spanning the extracellular domain exons 2 to 4 were amplified from each variant gene by polymerase chain reaction and determined by direct DNA sequencing. Comparison of nucleotide sequences encompassing the third intron showed that the three hybrid genes differed in location of crossing-over sites. The alpha-delta breakpoints in MiV and MiV(J.L.) genes were localized to the 3′ end of the HindIII site downstream from exon 3 and to the 5′ end immediately upstream from exon 4, respectively, whereas the delta-alpha breakpoint in Sta gene resided in between. An AAAGT sequence oriented in either forward or reverse direction was identified within the crossing-over region of each hybrid gene whose surrounding sequences bear a strong local strand asymmetry. The single nucleotide substitution in exon 4 of MiV and MiV(J.L.) genes (ACG [Thr] to ATG [Met]) demonstrated that the two genes differed in the delta glycophorin alleles that must have participated in the recombination." @default.
- W343150300 created "2016-06-24" @default.
- W343150300 creator A5036782713 @default.
- W343150300 creator A5072940415 @default.
- W343150300 date "1991-04-15" @default.
- W343150300 modified "2023-10-03" @default.
- W343150300 title "Identification of recombination events resulting in three hybrid genes encoding human MiV, MiV(J.L.), and Sta glycophorins" @default.
- W343150300 cites W1485799257 @default.
- W343150300 cites W1499349210 @default.
- W343150300 cites W1530420643 @default.
- W343150300 cites W1548899838 @default.
- W343150300 cites W1553335871 @default.
- W343150300 cites W1561477659 @default.
- W343150300 cites W1584420390 @default.
- W343150300 cites W1608298331 @default.
- W343150300 cites W1987932215 @default.
- W343150300 cites W1988484106 @default.
- W343150300 cites W2002637279 @default.
- W343150300 cites W2007815804 @default.
- W343150300 cites W2013246942 @default.
- W343150300 cites W2014669590 @default.
- W343150300 cites W2015058713 @default.
- W343150300 cites W2018972218 @default.
- W343150300 cites W2023326195 @default.
- W343150300 cites W2025145884 @default.
- W343150300 cites W2032118018 @default.
- W343150300 cites W2038718616 @default.
- W343150300 cites W2046857454 @default.
- W343150300 cites W2047043554 @default.
- W343150300 cites W2057042461 @default.
- W343150300 cites W2059552445 @default.
- W343150300 cites W2063116287 @default.
- W343150300 cites W2063450941 @default.
- W343150300 cites W2138270253 @default.
- W343150300 cites W2144634347 @default.
- W343150300 cites W2312269164 @default.
- W343150300 cites W2409784901 @default.
- W343150300 cites W2467030417 @default.
- W343150300 cites W2885709021 @default.
- W343150300 cites W2334803333 @default.
- W343150300 doi "https://doi.org/10.1182/blood.v77.8.1813.1813" @default.
- W343150300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2015404" @default.
- W343150300 hasPublicationYear "1991" @default.
- W343150300 type Work @default.
- W343150300 sameAs 343150300 @default.
- W343150300 citedByCount "38" @default.
- W343150300 countsByYear W3431503002012 @default.
- W343150300 countsByYear W3431503002013 @default.
- W343150300 countsByYear W3431503002016 @default.
- W343150300 countsByYear W3431503002019 @default.
- W343150300 countsByYear W3431503002020 @default.
- W343150300 crossrefType "journal-article" @default.
- W343150300 hasAuthorship W343150300A5036782713 @default.
- W343150300 hasAuthorship W343150300A5072940415 @default.
- W343150300 hasBestOaLocation W3431503001 @default.
- W343150300 hasConcept C104317684 @default.
- W343150300 hasConcept C147483822 @default.
- W343150300 hasConcept C153911025 @default.
- W343150300 hasConcept C206936463 @default.
- W343150300 hasConcept C30481170 @default.
- W343150300 hasConcept C36823959 @default.
- W343150300 hasConcept C54355233 @default.
- W343150300 hasConcept C67982717 @default.
- W343150300 hasConcept C86803240 @default.
- W343150300 hasConcept C94671646 @default.
- W343150300 hasConceptScore W343150300C104317684 @default.
- W343150300 hasConceptScore W343150300C147483822 @default.
- W343150300 hasConceptScore W343150300C153911025 @default.
- W343150300 hasConceptScore W343150300C206936463 @default.
- W343150300 hasConceptScore W343150300C30481170 @default.
- W343150300 hasConceptScore W343150300C36823959 @default.
- W343150300 hasConceptScore W343150300C54355233 @default.
- W343150300 hasConceptScore W343150300C67982717 @default.
- W343150300 hasConceptScore W343150300C86803240 @default.
- W343150300 hasConceptScore W343150300C94671646 @default.
- W343150300 hasIssue "8" @default.
- W343150300 hasLocation W3431503001 @default.
- W343150300 hasOpenAccess W343150300 @default.
- W343150300 hasPrimaryLocation W3431503001 @default.
- W343150300 hasRelatedWork W1967095384 @default.
- W343150300 hasRelatedWork W1982707814 @default.
- W343150300 hasRelatedWork W2030572150 @default.
- W343150300 hasRelatedWork W2037918956 @default.
- W343150300 hasRelatedWork W2038165705 @default.
- W343150300 hasRelatedWork W2039352533 @default.
- W343150300 hasRelatedWork W2054014494 @default.
- W343150300 hasRelatedWork W2073534395 @default.
- W343150300 hasRelatedWork W2092554027 @default.
- W343150300 hasRelatedWork W4242521457 @default.
- W343150300 hasVolume "77" @default.
- W343150300 isParatext "false" @default.
- W343150300 isRetracted "false" @default.
- W343150300 magId "343150300" @default.
- W343150300 workType "article" @default.