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- W34348768 abstract "Abstract Formation of new biological tissues by tissue engineering is achieved in vitro and in vivo by cells that are regulated by certain growth factors/cytokines and by matrices with specific structures. The extracellular matrix (ECM) is a complex ordered structure that contains multiple components (collagens, proteoglycans, structural glycoproteins and elastin) of macromolecules. The composition of the ECM is not static; rather it changes during normal development and tissue repair and regeneration. The ECM is the optimized structural milieu that maintains cell homeostasis and directs tissue development. Tissue engineering generally requires an artificial ECM for tissue regeneration. Otherwise, cell proliferation and differentiation, resulting in tissue regeneration, would be difficult unless such a matrix is provided that functions as a natural ECM. Placed at the site of a defect, such materials should actively and temporarily participate in the regeneration process by providing a platform on which cell-triggered remodeling could occur. Furthermore, since this artificial ECM should disappear through absorption into the body after implantation and when the new tissue is regenerated, it is preferable that materials for the matrix are prepared from biodegradable polymers to assist tissue regeneration." @default.
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- W34348768 date "2009-01-01" @default.
- W34348768 modified "2023-10-16" @default.
- W34348768 title "Artificial biomaterials for urological tissue engineering" @default.
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- W34348768 doi "https://doi.org/10.1533/9781845696375.3.243" @default.
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