FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W34377079> ?p ?o ?g. }

• W34377079 abstract "The development of muticellular organisms requires precisely regulated cell-cell communication mediated by numerous signal transduction pathways. Regulatory is essential in integrating the many inputs and stimuli that each cell receives, and ensuring that a cell responds appropriately. Drosophila nemo (nmo) is the founding member of an evolutionarily conserved family of serirdthreonine protein kinases kinases that are involved in several Wnt signal transduction pathways. Consistent with these findings, the detailed genetic analyses of the role of Nemo in Drosophila wing development support the proposed antagonistic role for Nemo in Drosophila Wingless (Wg) signaling pathway. In addition, I provide evidence that transcription of nmo is induced by high levels of Wg signaling in the developing wing disc. Our results indicate that Nemo acts as an intracellular feedback inhibitor of Wg during wing development and that it is a novel Wg target gene. In this study, a novel function for Nemo in inhibition of Drosophila Bone Morphogenetic Protein (BMP) signalling is also revealed. Genetic interaction studies demonstrate that nmo can antagonize BMP signaling and can inhibit the expression of BMP dependent target genes during wing development. Nemo can bind to and phosphorylate the BMP effectors Mad and Medea. In cell culture, phosphorylation by Nemo blocks the nuclear translocation of Mad. Mutation of a single Nemo phosphorylation site in Mad relieves the inhibition of nuclear translocation, and causes ligand-independent nuclear translocation. This is the first example of inhibition of Drosophila BMP signaling by a MAPK and also represents an original mechanism of Smad inhibition through phosphorylation of a conserved Serine residue within the MHI domain of Mad. In Drosophila wing imaginal disc development, Wg signalling pathway organizes the dorsal-ventral (DV) axis, while BMP signaling pathway is required to pattern the anterior-posterior (AP) axis. In the analyses of the roles of Nemo in Wg and BMP signaling pathways, a novel crosstalk between Wg and Dpp signaling is unveiled, in which Wg-dependent gene expression is suppressed by ectopic Dpp signaling. In addition, Arm and Mad compete for the binding of dTCF in cell culture. Consistently, in vivo, supplement of dTCF is able to rescue the suppression of Wg-dependent gene expression caused by ectopic Mad. Our results suggest a novel mechanism that Dpp represses Wg target gene by influencing the binding of Arm and dTCF." @default.
• W34377079 created "2016-06-24" @default.
• W34377079 creator A5016791091 @default.
• W34377079 date "2005-01-01" @default.
• W34377079 modified "2023-09-27" @default.
• W34377079 title "Characterization of drosophila nemo kinase, a conserved modulator of Wnt and TGF? signal transduction" @default.
• W34377079 cites W1485377536 @default.
• W34377079 cites W152375048 @default.
• W34377079 cites W1529816420 @default.
• W34377079 cites W1588334150 @default.
• W34377079 cites W1588637701 @default.
• W34377079 cites W1662963035 @default.
• W34377079 cites W1672956489 @default.
• W34377079 cites W1777605394 @default.
• W34377079 cites W1819307633 @default.
• W34377079 cites W1825806483 @default.
• W34377079 cites W1840163537 @default.
• W34377079 cites W1852286056 @default.
• W34377079 cites W1908701485 @default.
• W34377079 cites W1923939500 @default.
• W34377079 cites W1964223904 @default.
• W34377079 cites W1968263279 @default.
• W34377079 cites W1968535218 @default.
• W34377079 cites W1972175683 @default.
• W34377079 cites W1973021296 @default.
• W34377079 cites W1973901969 @default.
• W34377079 cites W1975853332 @default.
• W34377079 cites W1976070390 @default.
• W34377079 cites W1977508482 @default.
• W34377079 cites W1978146894 @default.
• W34377079 cites W1979518793 @default.
• W34377079 cites W1980415233 @default.
• W34377079 cites W1989215255 @default.
• W34377079 cites W1989962446 @default.
• W34377079 cites W1993038327 @default.
• W34377079 cites W1994738588 @default.
• W34377079 cites W1997180986 @default.
• W34377079 cites W1999141408 @default.
• W34377079 cites W2000978157 @default.
• W34377079 cites W2002953019 @default.
• W34377079 cites W2004753972 @default.
• W34377079 cites W2005792688 @default.
• W34377079 cites W2009455581 @default.
• W34377079 cites W2012039807 @default.
• W34377079 cites W2014748872 @default.
• W34377079 cites W2026533505 @default.
• W34377079 cites W2027197247 @default.
• W34377079 cites W2029469952 @default.
• W34377079 cites W2030603455 @default.
• W34377079 cites W2037274171 @default.
• W34377079 cites W2038243095 @default.
• W34377079 cites W2043377295 @default.
• W34377079 cites W2049829724 @default.
• W34377079 cites W2052142480 @default.
• W34377079 cites W2052873348 @default.
• W34377079 cites W2055102377 @default.
• W34377079 cites W2059030354 @default.
• W34377079 cites W2066277462 @default.
• W34377079 cites W2067785100 @default.
• W34377079 cites W2072243112 @default.
• W34377079 cites W2076304265 @default.
• W34377079 cites W2076650770 @default.
• W34377079 cites W2076914475 @default.
• W34377079 cites W2078402042 @default.
• W34377079 cites W2080213723 @default.
• W34377079 cites W2081689397 @default.
• W34377079 cites W2082476863 @default.
• W34377079 cites W2082867992 @default.
• W34377079 cites W2083905520 @default.
• W34377079 cites W2090636859 @default.
• W34377079 cites W2090851532 @default.
• W34377079 cites W2093520291 @default.
• W34377079 cites W2096898215 @default.
• W34377079 cites W2099300824 @default.
• W34377079 cites W2102512718 @default.
• W34377079 cites W2104265411 @default.
• W34377079 cites W2105556617 @default.
• W34377079 cites W2105571987 @default.
• W34377079 cites W2109744312 @default.
• W34377079 cites W2113695281 @default.
• W34377079 cites W2117924228 @default.
• W34377079 cites W2118625918 @default.
• W34377079 cites W2119284420 @default.
• W34377079 cites W2120865645 @default.
• W34377079 cites W2124772662 @default.
• W34377079 cites W2128652025 @default.
• W34377079 cites W2131783587 @default.
• W34377079 cites W2137389347 @default.
• W34377079 cites W2138222765 @default.
• W34377079 cites W2138753762 @default.
• W34377079 cites W2145617194 @default.
• W34377079 cites W2146150648 @default.
• W34377079 cites W2146167376 @default.
• W34377079 cites W2148535443 @default.
• W34377079 cites W2154568166 @default.
• W34377079 cites W2158595559 @default.
• W34377079 cites W2159935247 @default.
• W34377079 cites W2160064773 @default.
• W34377079 cites W2165047377 @default.
• W34377079 cites W2165781463 @default.

• next