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- W344142480 abstract "ABSTRACT The chronic administration of d-amphetamine (AM) produces two apparently opposed responses - tolerance and hypersensitivity. We have investigated the possibility that the scheduling of AM might be an important determinant as to which of these two responses occurs. Sprague-Dawley rats were injected with 5 mg/kg AM once daily (group 1), 1.5 mg/kg once daily (group 2), 5 mg/kg every other day (group 3) or with saline alone (group 4). In groups 1 and 2, the first injection of AM produced an intense behavioral arousal manifested by the early appearance of stereotyped behavior (AISB) which quickly overwhelmed and completely blocked AM induced locomotor activity (AILA) within 30 minutes of injection. 3 days after the final injection of AM, all 4 groups received 0.25 mg/kg AM. Animals in groups 1 and 2 (daily AM) exhibited a hypersensitive response relative to the control group. Group 3, receiving AM every other day, displayed tolerance, with AILA of that group being 1.5x less than that of controls. This represents the first true demonstration of tolerance to AISB and AILA." @default.
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- W344142480 date "1979-01-01" @default.
- W344142480 modified "2023-09-24" @default.
- W344142480 title "THE ROLE OF SCHEDULING IN AMPHETAMINE HYPERSENSITIVITY AND TOLERANCE" @default.
- W344142480 cites W1969155848 @default.
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- W344142480 doi "https://doi.org/10.1016/b978-1-4832-8363-0.50503-6" @default.
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