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- W344161036 abstract "Abstract : Isolated lungs were perfused 1.5 hours with a medium of washed bovine red cells resuspended to a 15 percent hematocrit with Krebs-Henseleit bicarbonate buffer containing 5 gram percent albumin. Substrate concentrations were 6 millimolar glucose and 1 millimolar palmitate. Data from altered carbon dioxide tension experiments indicate that prior exposure to high carbon dioxide tension markedly alters the lung's ability to maintain synthesis of cellular constituents from glucose. In a second series of experiments acute effects of hyperoxia on lung metabolism were examined. Lactate production increased and pyruvate decreased. Data from a series of test of hypoxia on cyclic nucleotides indicate that hypoxia has a selective action on lung cAMP and nutritional stress potentiates a hypoxic-hypercapnia exposure drastically alters lung weight, glycolysis and lipid synthesis in the lung. (Author)" @default.
- W344161036 created "2016-06-24" @default.
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- W344161036 date "1976-09-01" @default.
- W344161036 modified "2023-09-24" @default.
- W344161036 title "Influence of Altered Gaseous Environments on Lung Metabolism." @default.
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