Matches in SemOpenAlex for { <https://semopenalex.org/work/W344512102> ?p ?o ?g. }
- W344512102 abstract "Cellular immortality is a hallmark of neoplastic transformation, the detection of which in vitro may be only limited by providing stringent culture conditions for neoplastic cells. Unlike cultured rodent cells, spontaneously immortal human mammary epithelial cell lines cultured from presumably normal cells have rarely been identified. Only two reports described cell lines that arose in mammary tissue explants obtained from women with fibrocystic disease or intraductal hyperplasia (Briand et al. 1987; Soule et al. 1990). For clarity, and by definition, a normal human mammary epithelial cell (HMEC) population or clone that eventually senesces in culture is termed a “strain”, while a clone or population that has unlimited replicative potential is termed a “line”. The principles and players that confer unlimited in vitro replicative potential upon HMEC strains overlap partially with findings from cultured human diploid lineages, e.g., fibroblast-like cells and keratinocytes. Similarities between immortalized fibroblast-like cultures and HMECs include the functional repression of cell cycle- and DNA damage responsive-proteins p53, pRB, p16, and p21 (reviewed in Campisi et al. 1996; Garkavtsev et al. 1998). Nonetheless, human HMECs have unique phenotypes and require stringent culture conditions. This chapter will be limited to a discussion of human-derived mammary epithelial cells." @default.
- W344512102 created "2016-06-24" @default.
- W344512102 creator A5061689130 @default.
- W344512102 date "1999-01-01" @default.
- W344512102 modified "2023-09-24" @default.
- W344512102 title "Concepts of Immortalization in Human Mammary Epithelial Cells" @default.
- W344512102 cites W1534866003 @default.
- W344512102 cites W1544851750 @default.
- W344512102 cites W1632349675 @default.
- W344512102 cites W1675635349 @default.
- W344512102 cites W1965217852 @default.
- W344512102 cites W1969179213 @default.
- W344512102 cites W1969793246 @default.
- W344512102 cites W1973667113 @default.
- W344512102 cites W1973812603 @default.
- W344512102 cites W1978538783 @default.
- W344512102 cites W1979165906 @default.
- W344512102 cites W1979890429 @default.
- W344512102 cites W1981373847 @default.
- W344512102 cites W1995776031 @default.
- W344512102 cites W1997169030 @default.
- W344512102 cites W1998335540 @default.
- W344512102 cites W1999646346 @default.
- W344512102 cites W2002263141 @default.
- W344512102 cites W2008880834 @default.
- W344512102 cites W2010344294 @default.
- W344512102 cites W2013229697 @default.
- W344512102 cites W2013292325 @default.
- W344512102 cites W2013880323 @default.
- W344512102 cites W2017414724 @default.
- W344512102 cites W2019994666 @default.
- W344512102 cites W2020333197 @default.
- W344512102 cites W2026543158 @default.
- W344512102 cites W2029735450 @default.
- W344512102 cites W2032193754 @default.
- W344512102 cites W2033909834 @default.
- W344512102 cites W2034176103 @default.
- W344512102 cites W2038983705 @default.
- W344512102 cites W2040588918 @default.
- W344512102 cites W2041112902 @default.
- W344512102 cites W2041988832 @default.
- W344512102 cites W2046168118 @default.
- W344512102 cites W2046786249 @default.
- W344512102 cites W2049927041 @default.
- W344512102 cites W2051496624 @default.
- W344512102 cites W2055247766 @default.
- W344512102 cites W2060786908 @default.
- W344512102 cites W2065359916 @default.
- W344512102 cites W2070012290 @default.
- W344512102 cites W2073225422 @default.
- W344512102 cites W2075211703 @default.
- W344512102 cites W2078396346 @default.
- W344512102 cites W2080308138 @default.
- W344512102 cites W2095156669 @default.
- W344512102 cites W2101688468 @default.
- W344512102 cites W2102606444 @default.
- W344512102 cites W2104908670 @default.
- W344512102 cites W2108482850 @default.
- W344512102 cites W2111053959 @default.
- W344512102 cites W2115076934 @default.
- W344512102 cites W2122003447 @default.
- W344512102 cites W2133663537 @default.
- W344512102 cites W2140014254 @default.
- W344512102 cites W2142946059 @default.
- W344512102 cites W2159141578 @default.
- W344512102 cites W87885556 @default.
- W344512102 doi "https://doi.org/10.1007/978-3-662-06227-2_7" @default.
- W344512102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10547862" @default.
- W344512102 hasPublicationYear "1999" @default.
- W344512102 type Work @default.
- W344512102 sameAs 344512102 @default.
- W344512102 citedByCount "1" @default.
- W344512102 countsByYear W3445121022020 @default.
- W344512102 crossrefType "book-chapter" @default.
- W344512102 hasAuthorship W344512102A5061689130 @default.
- W344512102 hasConcept C104317684 @default.
- W344512102 hasConcept C121608353 @default.
- W344512102 hasConcept C127716648 @default.
- W344512102 hasConcept C144024400 @default.
- W344512102 hasConcept C1491633281 @default.
- W344512102 hasConcept C149923435 @default.
- W344512102 hasConcept C203014093 @default.
- W344512102 hasConcept C2780381497 @default.
- W344512102 hasConcept C2908647359 @default.
- W344512102 hasConcept C2993273003 @default.
- W344512102 hasConcept C54355233 @default.
- W344512102 hasConcept C555283112 @default.
- W344512102 hasConcept C6045943 @default.
- W344512102 hasConcept C81089528 @default.
- W344512102 hasConcept C81885089 @default.
- W344512102 hasConcept C86803240 @default.
- W344512102 hasConcept C95444343 @default.
- W344512102 hasConceptScore W344512102C104317684 @default.
- W344512102 hasConceptScore W344512102C121608353 @default.
- W344512102 hasConceptScore W344512102C127716648 @default.
- W344512102 hasConceptScore W344512102C144024400 @default.
- W344512102 hasConceptScore W344512102C1491633281 @default.
- W344512102 hasConceptScore W344512102C149923435 @default.
- W344512102 hasConceptScore W344512102C203014093 @default.
- W344512102 hasConceptScore W344512102C2780381497 @default.