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- W34504530 abstract "Publisher Summary A long-held goal of neurobiology has been to identify mechanisms that promote the survival of forebrain neurons and, in particular, the role of neurotrophic factors in sustaining neuronal viability and coordinating adaptive responses to insult. Progress has been made in identifying endogenous mechanisms that regulate the expression of the neurotrophic factors in the brain and periphery. Research in the laboratory has focused on the regulation of neurotrophic factor expression by neuronal activity. This work began with the discovery that seizures stimulate a large increase in the expression of nerve growth factor (NGF) by forebrain neurons. The expression of NGF and of structurally related neurotrophins in adult brain responds to a variety of manipulations ranging from known triggers for pathogenesis (e.g., transient ischemia) to events not unlike those which occur during the course of normal network operations (e.g., rhythmic bursts of afferent activity). One of the more striking features of neurotrophic factor regulation by physiological activity is that the response to neuronal activity is highly cell specific. The influences of activity are strikingly cell specific and reflect interactions with the hormonal environment." @default.
- W34504530 created "2016-06-24" @default.
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- W34504530 date "1995-01-01" @default.
- W34504530 modified "2023-09-26" @default.
- W34504530 title "Stimulation of Neurotrophic Factor Expression: Links to Different Forms of Brain Plasticity" @default.
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- W34504530 doi "https://doi.org/10.1016/b978-0-08-042527-6.50024-9" @default.
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