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- W345110470 abstract "The RNA-binding proteins involved in regulation of mRNA post-transcriptional processing and translation control the fates of thousands of mRNA transcripts and basic cellular processes. The best studied of these, HuR, is well characterized as a mediator of mRNA stability and translation, and more recently, as a factor in nuclear functions such as pre-mRNA splicing. Due to HuR's role in regulating thousands of mRNA transcripts, including those for other RNA-binding proteins, HuR can act as a master regulator of cell survival and proliferation. HuR itself is subject to multiple post-translational modifications including regulation of its nucleocytoplasmic distribution. However, the mechanisms that govern HuR levels in the cell have only recently begun to be defined. These mechanisms are critical to cell health, as it has become clear in recent years that aberrant expression of HuR can lead alternately to decreased cell viability or to promotion of pathological proliferation and invasiveness. HuR is expressed as alternate mRNAs that vary in their untranslated regions, leading to differences in transcript stability and translatability. Multiple transcription factors and modulators of mRNA stability that regulate HuR mRNA expression have been identified. In addition, translation of HuR is regulated by numerous microRNAs, several of which have been demonstrated to have anti-tumor properties due to their suppression of HuR expression. This review summarizes the current state of knowledge of the factors that regulate HuR expression, along with the circumstances under which these factors contribute to cancer and inflammation." @default.
- W345110470 created "2016-06-24" @default.
- W345110470 creator A5025937724 @default.
- W345110470 creator A5058615765 @default.
- W345110470 date "2013-01-01" @default.
- W345110470 modified "2023-10-08" @default.
- W345110470 title "Adaptive and maladaptive expression of the Mrna regulatory protein HuR" @default.
- W345110470 cites W1492237306 @default.
- W345110470 cites W1585042264 @default.
- W345110470 cites W1964805922 @default.
- W345110470 cites W1971904680 @default.
- W345110470 cites W1975221809 @default.
- W345110470 cites W1976238769 @default.
- W345110470 cites W1978521302 @default.
- W345110470 cites W1981565186 @default.
- W345110470 cites W1982125065 @default.
- W345110470 cites W1982369409 @default.
- W345110470 cites W1985563073 @default.
- W345110470 cites W1989847489 @default.
- W345110470 cites W1991334675 @default.
- W345110470 cites W1991423906 @default.
- W345110470 cites W1993345123 @default.
- W345110470 cites W1994720844 @default.
- W345110470 cites W2001453032 @default.
- W345110470 cites W2007011637 @default.
- W345110470 cites W2012112428 @default.
- W345110470 cites W2013073866 @default.
- W345110470 cites W2013331123 @default.
- W345110470 cites W2013558416 @default.
- W345110470 cites W2013855617 @default.
- W345110470 cites W2015725486 @default.
- W345110470 cites W2019563964 @default.
- W345110470 cites W2025406975 @default.
- W345110470 cites W2025947523 @default.
- W345110470 cites W2026541961 @default.
- W345110470 cites W2030248691 @default.
- W345110470 cites W2033180466 @default.
- W345110470 cites W2033765773 @default.
- W345110470 cites W2036755333 @default.
- W345110470 cites W2038413819 @default.
- W345110470 cites W2045228008 @default.
- W345110470 cites W2048254997 @default.
- W345110470 cites W2049462796 @default.
- W345110470 cites W2050108172 @default.
- W345110470 cites W2052936234 @default.
- W345110470 cites W2054630268 @default.
- W345110470 cites W2056766314 @default.
- W345110470 cites W2059646461 @default.
- W345110470 cites W2060708740 @default.
- W345110470 cites W2069192087 @default.
- W345110470 cites W2074915514 @default.
- W345110470 cites W2081886897 @default.
- W345110470 cites W2083123268 @default.
- W345110470 cites W2086534524 @default.
- W345110470 cites W2087702912 @default.
- W345110470 cites W2088398279 @default.
- W345110470 cites W2089913183 @default.
- W345110470 cites W2099021337 @default.
- W345110470 cites W2099778594 @default.
- W345110470 cites W2100428516 @default.
- W345110470 cites W2102482931 @default.
- W345110470 cites W2104119190 @default.
- W345110470 cites W2108931269 @default.
- W345110470 cites W2124835931 @default.
- W345110470 cites W2125043493 @default.
- W345110470 cites W2125524603 @default.
- W345110470 cites W2130932394 @default.
- W345110470 cites W2150582334 @default.
- W345110470 cites W2154657480 @default.
- W345110470 cites W2159394259 @default.
- W345110470 cites W2162990291 @default.
- W345110470 cites W2163779987 @default.
- W345110470 cites W2163994278 @default.
- W345110470 cites W2164840475 @default.
- W345110470 cites W2168456732 @default.
- W345110470 cites W2168759699 @default.
- W345110470 cites W2170375626 @default.
- W345110470 cites W2334761118 @default.
- W345110470 doi "https://doi.org/10.4331/wjbc.v4.i4.111" @default.
- W345110470 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3856306" @default.
- W345110470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24340134" @default.
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