Matches in SemOpenAlex for { <https://semopenalex.org/work/W34513397> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W34513397 endingPage "641" @default.
- W34513397 startingPage "635" @default.
- W34513397 abstract "This chapter investigates the potential genetic contribution of deiodinase type 2 (DIO2), performing a case-control association study using three common SNPs in the gene (rs225014, rs225012, and rs225010) that were in strong linkage disequilibrium with each other. Thyroid hormone (TH) plays an important role in fetal and early postnatal brain development. The pro-hormone T4 is converted in the brain to its active form, T3, or its inactive metabolite; reverse T3, mainly by the action of DIO2. MR is a disability characterized by significant limitations both in intellectual functioning and in adaptive behavior. The disability is often congenital and present at birth, but by definition must be present before age 18. A case-control association study using SNPs in the DIO2 gene was performed and DIO2 was found to be associated with MR in iodine-deficient areas. The normal DIO2 enzyme activity, especially local enzyme activity in the brain, may be an important protection factor of brain development from the late first trimester and early second trimester of gestation. It can be concluded that allelic variation in the DIO2 gene may affect the amount of T3 available and, in an iodine-deficient environment, partly determine the overall risk of MR. The results suggested that DIO2 enzyme activity, especially local enzyme activity in the brain, may have an important contribution to brain development." @default.
- W34513397 created "2016-06-24" @default.
- W34513397 creator A5026889389 @default.
- W34513397 creator A5082799387 @default.
- W34513397 creator A5085629666 @default.
- W34513397 date "2009-01-01" @default.
- W34513397 modified "2023-10-15" @default.
- W34513397 title "The Deiodinase Type 2 (DIO2) Gene and Mental Retardation in Iodine Deficiency" @default.
- W34513397 cites W1872875179 @default.
- W34513397 cites W1915701605 @default.
- W34513397 cites W1965534308 @default.
- W34513397 cites W1966103886 @default.
- W34513397 cites W1968946983 @default.
- W34513397 cites W1977986304 @default.
- W34513397 cites W1980113310 @default.
- W34513397 cites W1996045304 @default.
- W34513397 cites W2015843695 @default.
- W34513397 cites W2029653372 @default.
- W34513397 cites W2035126508 @default.
- W34513397 cites W2049733192 @default.
- W34513397 cites W2074099014 @default.
- W34513397 cites W2083022748 @default.
- W34513397 cites W2086286256 @default.
- W34513397 cites W2097504226 @default.
- W34513397 cites W2104691869 @default.
- W34513397 cites W2107095755 @default.
- W34513397 cites W2110755408 @default.
- W34513397 cites W2115582509 @default.
- W34513397 cites W2127811896 @default.
- W34513397 cites W2142718693 @default.
- W34513397 cites W2166554867 @default.
- W34513397 cites W2955396174 @default.
- W34513397 doi "https://doi.org/10.1016/b978-0-12-374135-6.00066-2" @default.
- W34513397 hasPublicationYear "2009" @default.
- W34513397 type Work @default.
- W34513397 sameAs 34513397 @default.
- W34513397 citedByCount "0" @default.
- W34513397 crossrefType "book-chapter" @default.
- W34513397 hasAuthorship W34513397A5026889389 @default.
- W34513397 hasAuthorship W34513397A5082799387 @default.
- W34513397 hasAuthorship W34513397A5085629666 @default.
- W34513397 hasConcept C104317684 @default.
- W34513397 hasConcept C126322002 @default.
- W34513397 hasConcept C134018914 @default.
- W34513397 hasConcept C135763542 @default.
- W34513397 hasConcept C139275648 @default.
- W34513397 hasConcept C153209595 @default.
- W34513397 hasConcept C171269688 @default.
- W34513397 hasConcept C2778288131 @default.
- W34513397 hasConcept C2778417266 @default.
- W34513397 hasConcept C54355233 @default.
- W34513397 hasConcept C71315377 @default.
- W34513397 hasConcept C71924100 @default.
- W34513397 hasConcept C86803240 @default.
- W34513397 hasConceptScore W34513397C104317684 @default.
- W34513397 hasConceptScore W34513397C126322002 @default.
- W34513397 hasConceptScore W34513397C134018914 @default.
- W34513397 hasConceptScore W34513397C135763542 @default.
- W34513397 hasConceptScore W34513397C139275648 @default.
- W34513397 hasConceptScore W34513397C153209595 @default.
- W34513397 hasConceptScore W34513397C171269688 @default.
- W34513397 hasConceptScore W34513397C2778288131 @default.
- W34513397 hasConceptScore W34513397C2778417266 @default.
- W34513397 hasConceptScore W34513397C54355233 @default.
- W34513397 hasConceptScore W34513397C71315377 @default.
- W34513397 hasConceptScore W34513397C71924100 @default.
- W34513397 hasConceptScore W34513397C86803240 @default.
- W34513397 hasLocation W345133971 @default.
- W34513397 hasOpenAccess W34513397 @default.
- W34513397 hasPrimaryLocation W345133971 @default.
- W34513397 hasRelatedWork W2005744729 @default.
- W34513397 hasRelatedWork W2070995469 @default.
- W34513397 hasRelatedWork W2079710179 @default.
- W34513397 hasRelatedWork W2114237571 @default.
- W34513397 hasRelatedWork W2155312245 @default.
- W34513397 hasRelatedWork W2163236351 @default.
- W34513397 hasRelatedWork W2164661085 @default.
- W34513397 hasRelatedWork W2169697618 @default.
- W34513397 hasRelatedWork W2172055973 @default.
- W34513397 hasRelatedWork W2547625788 @default.
- W34513397 isParatext "false" @default.
- W34513397 isRetracted "false" @default.
- W34513397 magId "34513397" @default.
- W34513397 workType "book-chapter" @default.