Matches in SemOpenAlex for { <https://semopenalex.org/work/W345587598> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W345587598 endingPage "443" @default.
- W345587598 startingPage "443" @default.
- W345587598 abstract "Treatment of malignant tumors is among challenging issues of clinical medicine. Dissemination and matestasis of tumor cells plays a major role in oncology, being immediately dependent on chemotaxis of tumor cells. Hence, the aim of our study is to evaluate migration of tumor cells, in terms of ligand-mediated chemotaxis of a human U 937 lymphoma cell line. Synthetic TLR ligands (DNA_lig, RNA_lig) were used as chemoattractants. Assessment of time-dependent TLR expression by the migrating cells (including TLR2, TLR3, TLR7, TLR9) was carried out by means of real-time PCR, using Boyden’s chamber system for the migration assays. We have revealed an increased cell migration towards DNA_ lig and TNFα gradient. Expression of TLR2, TLR7 and TLR9 was found to be increased under the influence of TNFα (respectively 1.5-, 4- and 19-fold). Under the influence of DNA_lig, TLR9 expression was 105-fold increased, whereas TLR3 expression was 2-fold higher, along with decrease of TLR2 expression. Expression of TLR 3 was shown to be 3-times higher under the influence of RNA_lig. The effects observed could be potentially applied for suppression of tumor cell chemotaxis by means of these ligands and by influencing different pathways of chemotaxis regulation." @default.
- W345587598 created "2016-06-24" @default.
- W345587598 creator A5023125261 @default.
- W345587598 creator A5046774965 @default.
- W345587598 creator A5060937806 @default.
- W345587598 creator A5061488168 @default.
- W345587598 creator A5063580717 @default.
- W345587598 creator A5072578046 @default.
- W345587598 date "2014-11-23" @default.
- W345587598 modified "2023-10-18" @default.
- W345587598 title "LIGAND INDUCED CHEMOTAXIS OF MACROPHAGE CELL LINE U937" @default.
- W345587598 doi "https://doi.org/10.15789/1563-0625-2014-5-443-448" @default.
- W345587598 hasPublicationYear "2014" @default.
- W345587598 type Work @default.
- W345587598 sameAs 345587598 @default.
- W345587598 citedByCount "1" @default.
- W345587598 countsByYear W3455875982019 @default.
- W345587598 crossrefType "journal-article" @default.
- W345587598 hasAuthorship W345587598A5023125261 @default.
- W345587598 hasAuthorship W345587598A5046774965 @default.
- W345587598 hasAuthorship W345587598A5060937806 @default.
- W345587598 hasAuthorship W345587598A5061488168 @default.
- W345587598 hasAuthorship W345587598A5063580717 @default.
- W345587598 hasAuthorship W345587598A5072578046 @default.
- W345587598 hasBestOaLocation W3455875981 @default.
- W345587598 hasConcept C104317684 @default.
- W345587598 hasConcept C108634530 @default.
- W345587598 hasConcept C13373296 @default.
- W345587598 hasConcept C136449434 @default.
- W345587598 hasConcept C137738243 @default.
- W345587598 hasConcept C150194340 @default.
- W345587598 hasConcept C153911025 @default.
- W345587598 hasConcept C170493617 @default.
- W345587598 hasConcept C17991360 @default.
- W345587598 hasConcept C190727270 @default.
- W345587598 hasConcept C203014093 @default.
- W345587598 hasConcept C2776709828 @default.
- W345587598 hasConcept C2778420691 @default.
- W345587598 hasConcept C2779138994 @default.
- W345587598 hasConcept C2779836521 @default.
- W345587598 hasConcept C2781236682 @default.
- W345587598 hasConcept C502942594 @default.
- W345587598 hasConcept C54166955 @default.
- W345587598 hasConcept C54355233 @default.
- W345587598 hasConcept C55493867 @default.
- W345587598 hasConcept C81885089 @default.
- W345587598 hasConcept C86803240 @default.
- W345587598 hasConcept C95444343 @default.
- W345587598 hasConceptScore W345587598C104317684 @default.
- W345587598 hasConceptScore W345587598C108634530 @default.
- W345587598 hasConceptScore W345587598C13373296 @default.
- W345587598 hasConceptScore W345587598C136449434 @default.
- W345587598 hasConceptScore W345587598C137738243 @default.
- W345587598 hasConceptScore W345587598C150194340 @default.
- W345587598 hasConceptScore W345587598C153911025 @default.
- W345587598 hasConceptScore W345587598C170493617 @default.
- W345587598 hasConceptScore W345587598C17991360 @default.
- W345587598 hasConceptScore W345587598C190727270 @default.
- W345587598 hasConceptScore W345587598C203014093 @default.
- W345587598 hasConceptScore W345587598C2776709828 @default.
- W345587598 hasConceptScore W345587598C2778420691 @default.
- W345587598 hasConceptScore W345587598C2779138994 @default.
- W345587598 hasConceptScore W345587598C2779836521 @default.
- W345587598 hasConceptScore W345587598C2781236682 @default.
- W345587598 hasConceptScore W345587598C502942594 @default.
- W345587598 hasConceptScore W345587598C54166955 @default.
- W345587598 hasConceptScore W345587598C54355233 @default.
- W345587598 hasConceptScore W345587598C55493867 @default.
- W345587598 hasConceptScore W345587598C81885089 @default.
- W345587598 hasConceptScore W345587598C86803240 @default.
- W345587598 hasConceptScore W345587598C95444343 @default.
- W345587598 hasIssue "5" @default.
- W345587598 hasLocation W3455875981 @default.
- W345587598 hasLocation W3455875982 @default.
- W345587598 hasOpenAccess W345587598 @default.
- W345587598 hasPrimaryLocation W3455875981 @default.
- W345587598 hasRelatedWork W124367702 @default.
- W345587598 hasRelatedWork W1588911958 @default.
- W345587598 hasRelatedWork W1964133468 @default.
- W345587598 hasRelatedWork W1981087308 @default.
- W345587598 hasRelatedWork W2019639427 @default.
- W345587598 hasRelatedWork W2046435095 @default.
- W345587598 hasRelatedWork W2074134575 @default.
- W345587598 hasRelatedWork W2093951219 @default.
- W345587598 hasRelatedWork W2122057816 @default.
- W345587598 hasRelatedWork W2938746831 @default.
- W345587598 hasVolume "16" @default.
- W345587598 isParatext "false" @default.
- W345587598 isRetracted "false" @default.
- W345587598 magId "345587598" @default.
- W345587598 workType "article" @default.