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- W34577262 abstract "Poly(..gamma..-glutamylcysteinyl)glycines, (..gamma..EC) /sub n/G, are functional analogues of metallothionein in Cd-resistant Datura innoxia cells in suspension culture. These peptides bind Cd and the addition of Cd to the growth medium induces their synthesis. The presence of peptide bonds through the ..gamma..-carboxyl group of glutamate indicates that these compounds are products of a biosynthetic pathway and are not directly encoded by structural genes. Their structure suggests that a peptidase, with a catalytic activity similar to ..gamma..-glutamyl transpeptidase, is responsible for their assembly using glutathione and an activated form of ..gamma..-glutamyl cysteine as precursors. Binding of Cd to (..gamma..EC)/sub n/ G elicits product removal. Increased synthesis of these peptides in response to Cd is also accompanied by overproduction of certain mRNA species. The nature of the regulation of this pathway by Cd is considered." @default.
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- W34577262 date "1986-04-01" @default.
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- W34577262 title "Biosynthesis of poly(. gamma. -glutamylcysteinyl)glycines. [Datura innoxia]" @default.
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