FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3460904> ?p ?o ?g. }

• W3460904 endingPage "1084" @default.
• W3460904 startingPage "1082" @default.
• W3460904 abstract "Pancreatic hamartomas occur extremely rarely. They may appear as solid masses or cystic forms and should be regarded as malformations rather than neoplasms [1]. Due to absence of characteristic differential features they may be clinically and radiologically mistaken for a malig7-18062cy [2]. Misinterpretation of hamartoma as a true neoplasm may result in unnecessarily aggressive surgery. The authors herein present a case report of solid pancreatic hamartoma and demonstrate its characteristics along with a review of the literature and discuss the problem of potential overtreatment of these patients.A 69-year-old male patient was presented with a hypoechogenic, asymptomatic pancreatic body mass, incidentally revealed by ultrasonography. The patient gave no medical history of either chronic pancreatitis or other diseases of the pancreas. Pancreatitis and neoplasm (CEA, CA 19-9) markers were within the normal range; pancreatic exocrine and endocrine function was sufficient. Further endosonography scans revealed a 28 mm × 22 mm hypoechogenic tumour-like lesion within the body of the pancreas (Figure 1). Computed tomography scans confirmed a solid tumor with ill-demarcated margin (Figure 2). The patient was qualified for surgical treatment. Intraoperatively, the oval, pancreatic body mass of firm consistency was confirmed. Central pancreatic resection with Roux-en-Y pancreaticojejunostomy to the distal pancreatic rem7-18062t was performed. The postoperative period was complicated by leakage from the pancreatojejunostomy. Reoperation with re-suturing of the anastomosis was applied. The remaining postoperative time was uneventful. So far, the patient has been followed up for 55 months and has remained disease-free.Figure 17.5 MHz radial EUS view of a 28 mm × 22 mm pancreatic corpus tumour-like lesionFigure 2Computed tomography revealing solid tumour within the body of the pancreasMacroscopically, a firm, solid, whitish, well-circumscribed, encapsulated mass measuring 3 cm in maximum diameter was confirmed. Histologically, the tumour was almost entirely composed of disorderly arranged, well-differentiated endocrine and exocrine pancreatic tissue (Figure 3). The spindle morphology of a small quantity of stroma cells and cystically dilated pancreatic ducts, filled with pancreatic juice, were observed (Figure 4). The tumour was surrounded by adjacent normal pancreatic parenchyma without significant fibrosis or features of chronic inflammation. Insulin, glucagon, chromogranin, somatostatin, amylase, CD34, CD117, S-100 and desmin immunostainings confirmed colocalization of the typical pancreatic cells. Surprisingly, immunohistochemical analysis of CD34 and CD117 showed a negative reaction in elongated stoma tumour cells. Therefore, the diagnosis of pancreatic hamartoma was established.Figure 3Exocrine part of the pancreas with islets and adipose tissue. HE, 120×Figure 4Dilated pancreatic ducts. HE, 120×Hamartomas of the pancreas are rarely reported, since only a few cases have been described in the literature. Clinicopathological features of all noted cases are summarized in Table I [2-10]. Some authors have observed that this kind of lesion includes spindle-shaped cells which are immunoreactive for CD34 and CD117 [9]. The descriptive term of these tumours as cellular hamartomas resembling gastrointestinal stromal tumours was suggested. In our case, pathological changes in the cellular shape of stroma cells were observed, although immunohistochemical tests for CD 34 and CD117 were non-contributory, which excludes such a pathological characterization. Table ICharacteristics of pancreatic hamartomas reported in the literatureThe histogenetic concept of hamartomas is enigmatic. Hamartomas of the pancreas were thought to coexist with chronic pancreatitis. On the other hand, Pauser et al. excluded such cases from this group. In the authors’ opinion, the term of hamartoma should be reserved for asymptomatic patients. The hypothesis that inflammation is one of the factors that induce hamartoma development is not valid, since chronic pancreatitis may just mimic hamartoma lesions lacking acinar cells.The natural course of hamartoma is not characteristic, as in our described case. Routine laboratory tests and imaging studies are non-contributory in establishment of the final diagnosis. Needle biopsy is suggested to be feasible in differential diagnosis. However, false negative results may occur frequently, and it may be associated with tumour cells seeding in malig7-18062cy. Thus, in the authors’ opinion, patients with solitary incidentaloma such as hamartoma of the pancreas should not undergo routine pancreatic tumour biopsy.Currently, preoperative differentiation between hamartomas or other benign tumours and malig7-18062cies is very difficult, if not in many cases impossible. As a consequence, it raises a question about treatment of patients with incidentally diagnosed solitary pancreatic tumour of unknown character. In view of the fact that pre-malig7-18062t and malig7-18062t histology of pancreatic asymptomatic incidentalomas is far more frequent, still surgical excision should be the treatment of choice, even though aggressive surgery may be overtreatment in patients among whom postoperative histopathological examination revealed hamartoma or other benign tumour.In conclusion, pancreatic hamartoma is an extremely rare medical problem. Misinterpretation of asymptomatic hamartomas as a true neoplasms may result in unnecessarily aggressive surgery. Nevertheless, preoperative diagnostic difficulties may be finally resolved only with histopathological examination of the postoperative specimen." @default.
• W3460904 created "2016-06-24" @default.
• W3460904 creator A5003432475 @default.
• W3460904 creator A5019091792 @default.
• W3460904 creator A5034501518 @default.
• W3460904 creator A5035540683 @default.
• W3460904 creator A5039230485 @default.
• W3460904 creator A5039986027 @default.
• W3460904 date "2011-01-01" @default.
• W3460904 modified "2023-10-16" @default.
• W3460904 title "Letters to Editor Asymptomatic solid pancreatic hamartoma" @default.
• W3460904 cites W1985698797 @default.
• W3460904 cites W1990930922 @default.
• W3460904 cites W2027508169 @default.
• W3460904 cites W2031811531 @default.
• W3460904 cites W2037330547 @default.
• W3460904 cites W2050567682 @default.
• W3460904 cites W2053447780 @default.
• W3460904 cites W2077674913 @default.
• W3460904 cites W2411343736 @default.
• W3460904 doi "https://doi.org/10.5114/aoms.2011.26624" @default.
• W3460904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3265004" @default.
• W3460904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22328895" @default.
• W3460904 hasPublicationYear "2011" @default.
• W3460904 type Work @default.
• W3460904 sameAs 3460904 @default.
• W3460904 citedByCount "19" @default.
• W3460904 countsByYear W34609042014 @default.
• W3460904 countsByYear W34609042015 @default.
• W3460904 countsByYear W34609042016 @default.
• W3460904 countsByYear W34609042017 @default.
• W3460904 countsByYear W34609042018 @default.
• W3460904 countsByYear W34609042019 @default.
• W3460904 countsByYear W34609042020 @default.
• W3460904 countsByYear W34609042021 @default.
• W3460904 countsByYear W34609042022 @default.
• W3460904 countsByYear W34609042023 @default.
• W3460904 crossrefType "journal-article" @default.
• W3460904 hasAuthorship W3460904A5003432475 @default.
• W3460904 hasAuthorship W3460904A5019091792 @default.
• W3460904 hasAuthorship W3460904A5034501518 @default.
• W3460904 hasAuthorship W3460904A5035540683 @default.
• W3460904 hasAuthorship W3460904A5039230485 @default.
• W3460904 hasAuthorship W3460904A5039986027 @default.
• W3460904 hasBestOaLocation W34609041 @default.
• W3460904 hasConcept C142724271 @default.
• W3460904 hasConcept C2775932916 @default.
• W3460904 hasConcept C2777910003 @default.
• W3460904 hasConcept C61434518 @default.
• W3460904 hasConcept C71924100 @default.
• W3460904 hasConceptScore W3460904C142724271 @default.
• W3460904 hasConceptScore W3460904C2775932916 @default.
• W3460904 hasConceptScore W3460904C2777910003 @default.
• W3460904 hasConceptScore W3460904C61434518 @default.
• W3460904 hasConceptScore W3460904C71924100 @default.
• W3460904 hasLocation W34609041 @default.
• W3460904 hasLocation W34609042 @default.
• W3460904 hasLocation W34609043 @default.
• W3460904 hasLocation W34609044 @default.
• W3460904 hasOpenAccess W3460904 @default.
• W3460904 hasPrimaryLocation W34609041 @default.
• W3460904 hasRelatedWork W129423339 @default.
• W3460904 hasRelatedWork W1987215768 @default.
• W3460904 hasRelatedWork W1991129960 @default.
• W3460904 hasRelatedWork W1995188757 @default.
• W3460904 hasRelatedWork W2007817983 @default.
• W3460904 hasRelatedWork W2016679923 @default.
• W3460904 hasRelatedWork W2116001782 @default.
• W3460904 hasRelatedWork W2943195325 @default.
• W3460904 hasRelatedWork W4229900919 @default.
• W3460904 hasRelatedWork W17604275 @default.
• W3460904 hasVolume "6" @default.
• W3460904 isParatext "false" @default.
• W3460904 isRetracted "false" @default.
• W3460904 magId "3460904" @default.
• W3460904 workType "article" @default.