FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W346514458> ?p ?o ?g. }

• W346514458 endingPage "1436" @default.
• W346514458 startingPage "1428" @default.
• W346514458 abstract "X-linked severe combined immunodeficiency (XSCID) is characterized by absent or profoundly reduced numbers of T cells and normal numbers of B cells in the circulation. Affected patients have mutations of the interleukin-2 (IL-2) receptor gamma chain gene. Using Epstein-Barr virus-transformed B-lymphoblastoid cell lines (B-LCLs) established from two unrelated XSCID patients, we could show that neither expressed the IL-2 receptor gamma chain on the cell surface. A novel cytokine IL-15, which has biologic activities similar to those of IL-2, could bind to the XSCID B-LCLs in the absence of the gamma chain, although both the beta and gamma chains of the human IL-2 receptor were previously shown to be required for IL-15 binding by transfected COS cells. Furthermore, a significant reduction and delay of IL-15 internalization by B lymphoblasts from XSCID patients was observed when compared with that of normal control B-LCLs. These results show the existence of a novel IL-15-specific receptor component that contributes to IL-15 binding but is insufficient for IL-15 internalization in the absence of the IL-2 receptor gamma chain." @default.
• W346514458 created "2016-06-24" @default.
• W346514458 creator A5012558697 @default.
• W346514458 creator A5038557052 @default.
• W346514458 creator A5039498179 @default.
• W346514458 creator A5041100375 @default.
• W346514458 creator A5050945744 @default.
• W346514458 creator A5062378629 @default.
• W346514458 creator A5067557904 @default.
• W346514458 creator A5075418720 @default.
• W346514458 creator A5079781502 @default.
• W346514458 creator A5087838405 @default.
• W346514458 date "1995-08-15" @default.
• W346514458 modified "2023-09-28" @default.
• W346514458 title "Characterization of B-cell lines established from two X-linked severe combined immunodeficiency patients: interleukin-15 binds to the B cells but is not internalized efficiently" @default.
• W346514458 cites W1487210663 @default.
• W346514458 cites W1520712400 @default.
• W346514458 cites W1547108495 @default.
• W346514458 cites W1554699584 @default.
• W346514458 cites W1567604499 @default.
• W346514458 cites W1969115085 @default.
• W346514458 cites W1971500432 @default.
• W346514458 cites W1972254316 @default.
• W346514458 cites W1987408160 @default.
• W346514458 cites W1992507820 @default.
• W346514458 cites W1993249556 @default.
• W346514458 cites W2006073656 @default.
• W346514458 cites W2009367713 @default.
• W346514458 cites W2021820438 @default.
• W346514458 cites W2021950135 @default.
• W346514458 cites W2072252693 @default.
• W346514458 cites W2083685529 @default.
• W346514458 cites W2084228983 @default.
• W346514458 cites W2095600542 @default.
• W346514458 cites W2098873212 @default.
• W346514458 cites W2121543473 @default.
• W346514458 cites W2125010485 @default.
• W346514458 cites W2415690018 @default.
• W346514458 doi "https://doi.org/10.1182/blood.v86.4.1428.bloodjournal8641428" @default.
• W346514458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7632950" @default.
• W346514458 hasPublicationYear "1995" @default.
• W346514458 type Work @default.
• W346514458 sameAs 346514458 @default.
• W346514458 citedByCount "37" @default.
• W346514458 countsByYear W3465144582013 @default.
• W346514458 countsByYear W3465144582016 @default.
• W346514458 crossrefType "journal-article" @default.
• W346514458 hasAuthorship W346514458A5012558697 @default.
• W346514458 hasAuthorship W346514458A5038557052 @default.
• W346514458 hasAuthorship W346514458A5039498179 @default.
• W346514458 hasAuthorship W346514458A5041100375 @default.
• W346514458 hasAuthorship W346514458A5050945744 @default.
• W346514458 hasAuthorship W346514458A5062378629 @default.
• W346514458 hasAuthorship W346514458A5067557904 @default.
• W346514458 hasAuthorship W346514458A5075418720 @default.
• W346514458 hasAuthorship W346514458A5079781502 @default.
• W346514458 hasAuthorship W346514458A5087838405 @default.
• W346514458 hasBestOaLocation W3465144581 @default.
• W346514458 hasConcept C113842279 @default.
• W346514458 hasConcept C139770010 @default.
• W346514458 hasConcept C153911025 @default.
• W346514458 hasConcept C159047783 @default.
• W346514458 hasConcept C170493617 @default.
• W346514458 hasConcept C187316574 @default.
• W346514458 hasConcept C191732599 @default.
• W346514458 hasConcept C197462201 @default.
• W346514458 hasConcept C203014093 @default.
• W346514458 hasConcept C207001950 @default.
• W346514458 hasConcept C2777371288 @default.
• W346514458 hasConcept C2778690821 @default.
• W346514458 hasConcept C2779468541 @default.
• W346514458 hasConcept C2908885563 @default.
• W346514458 hasConcept C54009773 @default.
• W346514458 hasConcept C54355233 @default.
• W346514458 hasConcept C81885089 @default.
• W346514458 hasConcept C86803240 @default.
• W346514458 hasConcept C98654944 @default.
• W346514458 hasConceptScore W346514458C113842279 @default.
• W346514458 hasConceptScore W346514458C139770010 @default.
• W346514458 hasConceptScore W346514458C153911025 @default.
• W346514458 hasConceptScore W346514458C159047783 @default.
• W346514458 hasConceptScore W346514458C170493617 @default.
• W346514458 hasConceptScore W346514458C187316574 @default.
• W346514458 hasConceptScore W346514458C191732599 @default.
• W346514458 hasConceptScore W346514458C197462201 @default.
• W346514458 hasConceptScore W346514458C203014093 @default.
• W346514458 hasConceptScore W346514458C207001950 @default.
• W346514458 hasConceptScore W346514458C2777371288 @default.
• W346514458 hasConceptScore W346514458C2778690821 @default.
• W346514458 hasConceptScore W346514458C2779468541 @default.
• W346514458 hasConceptScore W346514458C2908885563 @default.
• W346514458 hasConceptScore W346514458C54009773 @default.
• W346514458 hasConceptScore W346514458C54355233 @default.
• W346514458 hasConceptScore W346514458C81885089 @default.
• W346514458 hasConceptScore W346514458C86803240 @default.
• W346514458 hasConceptScore W346514458C98654944 @default.
• W346514458 hasIssue "4" @default.
• W346514458 hasLocation W3465144581 @default.

• next