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- W346687034 abstract "Objective To study the clinical features and immune components of chronic hepatitis B patients with hepatitis E virus super-infection. Method 30 cases of chronic hepatitis B patients diagnosed with hepatitis E infection and 30 chronic hepatitis B patients at the same period were studied. ELISA was used to detect the antigens and antibodies of hepatitis E and hepatitis B virus. HBV-DNA was detected by RT-PCR. The liver function,IL-4, TNF-α,IFN-γ,Th1 / Th2 of serum were measured and compared between the two groups of patients at the first and 8th week after treatment. Result Patients with HEV super-infection had a higher incidence of developing severe hepatitis (9 cases versus 6 cases,P0.05),a high proportion of HBV e antigen serum conversion (n=2 versus 1 cases) and a high level of serum ALT and TBIL. Compared to the control group, the level of IL-4 was low (P 0.05);the levels of TNF-α,IFN-γ were not changed (P0.05)and the ratio of Th1 / Th2 increased significantly (P 0.05). Conclusion HEV super-infection would in the severity of chronic hepatitis B infection. It may be due to the reduced production of anti-inflammatory cytokines IL-4 and the increased in cellular immunity which caused a large number of liver cells damage." @default.
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- W346687034 date "2009-01-01" @default.
- W346687034 modified "2023-09-23" @default.
- W346687034 title "The role of Th1 and Th2 in patients with chronic hepatitis B and HEV infection." @default.
- W346687034 hasPublicationYear "2009" @default.
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