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- W346688284 abstract "Telomeres protect the ends of all linear chromosomes against DNA loss and faulty recombination. They shorten during replication and also in response to external stress and damage. Telomerase counteracts telomere shortening but has nontelomeric functions as well. Shortened or otherwise uncapped telomeres are recognized by the cell's DNA damage response machinery and induce apoptosis or cell senescence, thus contributing to functional decline during aging. In humans and many other animals, telomeres in somatic tissues shorten with age. Telomere length in such tissues is associated with aging but currently lacks the diagnostic precision needed for it to be a reliable biomarker. Telomeres and telomerase, however, are promising targets for interventions to limit tumor growth and possibly to slow down age-related functional decline." @default.
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- W346688284 date "2014-01-01" @default.
- W346688284 modified "2023-09-23" @default.
- W346688284 title "Aging and Telomeres" @default.
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- W346688284 doi "https://doi.org/10.1016/b978-0-12-801238-3.00018-0" @default.
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