Matches in SemOpenAlex for { <https://semopenalex.org/work/W34683467> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W34683467 startingPage "6" @default.
- W34683467 abstract "BACKGROUND 1,1 ,2,2-Tetrachloroethane was widely used in the production of solvents and pesticides. Its production ended in the 1990s, but it is a major component of waste sites. We studied the effects of 1,1 ,2,2-tetrachloroethane on male and female rats and mice to identify potential toxic hazards to humans. METHODS Because 1,1,2,2-tetrachloroethane can evaporate easily, we enclosed it in starch microcapsules and placed them in the feed of rats and mice for 14 weeks. Male and female rats received up to 4,600 parts per million (ppm) 1,1 ,2,2-tetrachloroethane (equivalent to 0.46%) and mice received up to 9,100 ppm (0.91%). Control animals received empty starch microcapsules in their feed. Tissues from more than 40 sites were examined in all control and high-dose animals; tissues with lesions were examined in the lower exposure groups until no lesions were observed. RESULTS Rats receiving 1,180 ppm or more 1,1,2,2-tetrachloroethane and mice receiving 2,300 ppm or more weighed less than the control animals. Male and female rats given 1,1 ,2,2-tetrachloroethane had pale and diseased livers and also had atrophy of the bone marrow and of the genital systems. Male and female mice given 1,1,2,2-tetrachloroethane had lesions of the liver and the bile duct. CONCLUSION We conclude that 1,1,2,2-tetrachloroethane at doses greater than 590 ppm in the feed was toxic to the liver of male and female rats. In mice, 1,1 ,2,2-tetrachloroethane was already known to cause cancer after long-term exposure. In these 14-week studies, 1,1 ,2,2-tetrachloroethane was toxic to the livers of male and female mice." @default.
- W34683467 created "2016-06-24" @default.
- W34683467 creator A5010939189 @default.
- W34683467 date "2004-03-01" @default.
- W34683467 modified "2023-09-27" @default.
- W34683467 title "NTP technical report on the toxicity studies of 1,1,2,2-tetrachloroethane (CAS No. 79-34-5) administered in microcapsules in feed to F344/N rats and B6C3F1 mice." @default.
- W34683467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15154018" @default.
- W34683467 hasPublicationYear "2004" @default.
- W34683467 type Work @default.
- W34683467 sameAs 34683467 @default.
- W34683467 citedByCount "3" @default.
- W34683467 countsByYear W346834672015 @default.
- W34683467 countsByYear W346834672022 @default.
- W34683467 crossrefType "journal-article" @default.
- W34683467 hasAuthorship W34683467A5010939189 @default.
- W34683467 hasConcept C126322002 @default.
- W34683467 hasConcept C134018914 @default.
- W34683467 hasConcept C185592680 @default.
- W34683467 hasConcept C2780007613 @default.
- W34683467 hasConcept C2781172350 @default.
- W34683467 hasConcept C29730261 @default.
- W34683467 hasConcept C42407357 @default.
- W34683467 hasConcept C71924100 @default.
- W34683467 hasConceptScore W34683467C126322002 @default.
- W34683467 hasConceptScore W34683467C134018914 @default.
- W34683467 hasConceptScore W34683467C185592680 @default.
- W34683467 hasConceptScore W34683467C2780007613 @default.
- W34683467 hasConceptScore W34683467C2781172350 @default.
- W34683467 hasConceptScore W34683467C29730261 @default.
- W34683467 hasConceptScore W34683467C42407357 @default.
- W34683467 hasConceptScore W34683467C71924100 @default.
- W34683467 hasIssue "49" @default.
- W34683467 hasLocation W346834671 @default.
- W34683467 hasLocation W346834672 @default.
- W34683467 hasOpenAccess W34683467 @default.
- W34683467 hasPrimaryLocation W346834671 @default.
- W34683467 hasRelatedWork W126998401 @default.
- W34683467 hasRelatedWork W1972711762 @default.
- W34683467 hasRelatedWork W1988141603 @default.
- W34683467 hasRelatedWork W2037246452 @default.
- W34683467 hasRelatedWork W2038165624 @default.
- W34683467 hasRelatedWork W2047917390 @default.
- W34683467 hasRelatedWork W2061360887 @default.
- W34683467 hasRelatedWork W2080908861 @default.
- W34683467 hasRelatedWork W2084388514 @default.
- W34683467 hasRelatedWork W2088118554 @default.
- W34683467 hasRelatedWork W2124352100 @default.
- W34683467 hasRelatedWork W2151392864 @default.
- W34683467 hasRelatedWork W2413893239 @default.
- W34683467 hasRelatedWork W2417452487 @default.
- W34683467 hasRelatedWork W2417751753 @default.
- W34683467 hasRelatedWork W3143835066 @default.
- W34683467 hasRelatedWork W39151325 @default.
- W34683467 hasRelatedWork W41183005 @default.
- W34683467 hasRelatedWork W44109229 @default.
- W34683467 hasRelatedWork W80553794 @default.
- W34683467 isParatext "false" @default.
- W34683467 isRetracted "false" @default.
- W34683467 magId "34683467" @default.
- W34683467 workType "article" @default.