Matches in SemOpenAlex for { <https://semopenalex.org/work/W346965751> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W346965751 endingPage "52" @default.
- W346965751 startingPage "346" @default.
- W346965751 abstract "Chronic myelogenous leukemia (CML) is triggered by the constitutively activated BCR-ABL oncoprotein and multiple downstream signaling pathways, including the Raf/MEK/ERK, Akt/mTOR, SRC, and STAT5 pathways. The BCR-ABL tyrosine kinase inhibitor imatinib is the standard treatment for CML. However, the development of imatinib resistance has become a new challenge for CML treatment. Here, we investigated the expression levels of the signaling pathways to explore the cause of imatinib resistance and seek new reversing drugs. Our results showed that abnormal activation of the BCR-ABL-independent Lyn/ERK signaling pathway was involved in imatinib-resistance of K562R cells. Furthermore, p-Lyn and p-ERK were up-regulated after treatment with imatinib alone. However, U0126, a MEK1/2 inhibitor, could counteract the up-regulation induced by imatinib, and the combination of imatinib and U0126 could overcome the resistance to imatinib in K562R cells. In conclusion, our studies suggest that the combination of imatinib and an inhibitor of the ERK signaling pathway may be effective in imatinib-resistant CML patients." @default.
- W346965751 created "2016-06-24" @default.
- W346965751 creator A5019837546 @default.
- W346965751 creator A5020100539 @default.
- W346965751 creator A5071904602 @default.
- W346965751 creator A5078706922 @default.
- W346965751 date "2014-05-01" @default.
- W346965751 modified "2023-09-23" @default.
- W346965751 title "The MEK1/2 inhibitor U0126 reverses imatinib resistance through down-regulating activation of Lyn/ERK signaling pathway in imatinib-resistant K562R leukemia cells." @default.
- W346965751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24855825" @default.
- W346965751 hasPublicationYear "2014" @default.
- W346965751 type Work @default.
- W346965751 sameAs 346965751 @default.
- W346965751 citedByCount "4" @default.
- W346965751 countsByYear W3469657512015 @default.
- W346965751 countsByYear W3469657512016 @default.
- W346965751 countsByYear W3469657512022 @default.
- W346965751 crossrefType "journal-article" @default.
- W346965751 hasAuthorship W346965751A5019837546 @default.
- W346965751 hasAuthorship W346965751A5020100539 @default.
- W346965751 hasAuthorship W346965751A5071904602 @default.
- W346965751 hasAuthorship W346965751A5078706922 @default.
- W346965751 hasConcept C121608353 @default.
- W346965751 hasConcept C126322002 @default.
- W346965751 hasConcept C170493617 @default.
- W346965751 hasConcept C175818844 @default.
- W346965751 hasConcept C185592680 @default.
- W346965751 hasConcept C2776960273 @default.
- W346965751 hasConcept C2777583451 @default.
- W346965751 hasConcept C2778461978 @default.
- W346965751 hasConcept C2778729363 @default.
- W346965751 hasConcept C2778820342 @default.
- W346965751 hasConcept C3019892230 @default.
- W346965751 hasConcept C42362537 @default.
- W346965751 hasConcept C502942594 @default.
- W346965751 hasConcept C55493867 @default.
- W346965751 hasConcept C57074206 @default.
- W346965751 hasConcept C62478195 @default.
- W346965751 hasConcept C71924100 @default.
- W346965751 hasConcept C75217442 @default.
- W346965751 hasConcept C86554907 @default.
- W346965751 hasConcept C98274493 @default.
- W346965751 hasConceptScore W346965751C121608353 @default.
- W346965751 hasConceptScore W346965751C126322002 @default.
- W346965751 hasConceptScore W346965751C170493617 @default.
- W346965751 hasConceptScore W346965751C175818844 @default.
- W346965751 hasConceptScore W346965751C185592680 @default.
- W346965751 hasConceptScore W346965751C2776960273 @default.
- W346965751 hasConceptScore W346965751C2777583451 @default.
- W346965751 hasConceptScore W346965751C2778461978 @default.
- W346965751 hasConceptScore W346965751C2778729363 @default.
- W346965751 hasConceptScore W346965751C2778820342 @default.
- W346965751 hasConceptScore W346965751C3019892230 @default.
- W346965751 hasConceptScore W346965751C42362537 @default.
- W346965751 hasConceptScore W346965751C502942594 @default.
- W346965751 hasConceptScore W346965751C55493867 @default.
- W346965751 hasConceptScore W346965751C57074206 @default.
- W346965751 hasConceptScore W346965751C62478195 @default.
- W346965751 hasConceptScore W346965751C71924100 @default.
- W346965751 hasConceptScore W346965751C75217442 @default.
- W346965751 hasConceptScore W346965751C86554907 @default.
- W346965751 hasConceptScore W346965751C98274493 @default.
- W346965751 hasIssue "5" @default.
- W346965751 hasLocation W3469657511 @default.
- W346965751 hasOpenAccess W346965751 @default.
- W346965751 hasPrimaryLocation W3469657511 @default.
- W346965751 hasRelatedWork W1607666343 @default.
- W346965751 hasRelatedWork W1978777017 @default.
- W346965751 hasRelatedWork W1995217826 @default.
- W346965751 hasRelatedWork W2004871448 @default.
- W346965751 hasRelatedWork W2100041900 @default.
- W346965751 hasRelatedWork W2556047608 @default.
- W346965751 hasRelatedWork W2572120445 @default.
- W346965751 hasRelatedWork W2620094379 @default.
- W346965751 hasRelatedWork W2979743675 @default.
- W346965751 hasRelatedWork W4246699559 @default.
- W346965751 hasVolume "69" @default.
- W346965751 isParatext "false" @default.
- W346965751 isRetracted "false" @default.
- W346965751 magId "346965751" @default.
- W346965751 workType "article" @default.