Matches in SemOpenAlex for { <https://semopenalex.org/work/W346979722> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W346979722 endingPage "110.17" @default.
- W346979722 startingPage "110.17" @default.
- W346979722 abstract "Abstract In humans, a functional CASPASE-12 (CASP12) gene has been identified only in persons of African and Southern Indian heritage. CASP12 has been suggested to play a regulatory role in response to bacterial pathogens and in promoting and increased susceptibility to sepsis by down-regulating the production of inflammatory cytokines such as interleukin-1 (IL1). The existence of a gene whose effect is deleterious, and which has been the subject of extensive negative selection in the rest of the human population, implies the simultaneous presence of some selective benefit for persons having CASP12. Given the importance of inflammatory immune responses in controlling the initial stages of infection, and the role that CASP12 plays in down-regulating inflammation, we hypothesize that pathogens which exploit the inflammatory response are restrained by an active CASP12 gene product. A number of candidate pathogens can be ruled out on the basis that IL1 is required for their clearance, while others may select for CASP12 by how they utilize the IL1 response as a part of their pathogenesis." @default.
- W346979722 created "2016-06-24" @default.
- W346979722 creator A5062871467 @default.
- W346979722 creator A5077480819 @default.
- W346979722 date "2011-04-01" @default.
- W346979722 modified "2023-09-25" @default.
- W346979722 title "A possible mechanism for maintenance of the deleterious allele of human <i>CASAPSE-12</i> (110.17)" @default.
- W346979722 doi "https://doi.org/10.4049/jimmunol.186.supp.110.17" @default.
- W346979722 hasPublicationYear "2011" @default.
- W346979722 type Work @default.
- W346979722 sameAs 346979722 @default.
- W346979722 citedByCount "0" @default.
- W346979722 crossrefType "journal-article" @default.
- W346979722 hasAuthorship W346979722A5062871467 @default.
- W346979722 hasAuthorship W346979722A5077480819 @default.
- W346979722 hasConcept C104317684 @default.
- W346979722 hasConcept C111472728 @default.
- W346979722 hasConcept C138885662 @default.
- W346979722 hasConcept C141231307 @default.
- W346979722 hasConcept C180754005 @default.
- W346979722 hasConcept C203014093 @default.
- W346979722 hasConcept C2776914184 @default.
- W346979722 hasConcept C2778384902 @default.
- W346979722 hasConcept C2780942790 @default.
- W346979722 hasConcept C2908647359 @default.
- W346979722 hasConcept C54355233 @default.
- W346979722 hasConcept C71924100 @default.
- W346979722 hasConcept C7386963 @default.
- W346979722 hasConcept C86803240 @default.
- W346979722 hasConcept C8891405 @default.
- W346979722 hasConcept C89611455 @default.
- W346979722 hasConcept C99454951 @default.
- W346979722 hasConceptScore W346979722C104317684 @default.
- W346979722 hasConceptScore W346979722C111472728 @default.
- W346979722 hasConceptScore W346979722C138885662 @default.
- W346979722 hasConceptScore W346979722C141231307 @default.
- W346979722 hasConceptScore W346979722C180754005 @default.
- W346979722 hasConceptScore W346979722C203014093 @default.
- W346979722 hasConceptScore W346979722C2776914184 @default.
- W346979722 hasConceptScore W346979722C2778384902 @default.
- W346979722 hasConceptScore W346979722C2780942790 @default.
- W346979722 hasConceptScore W346979722C2908647359 @default.
- W346979722 hasConceptScore W346979722C54355233 @default.
- W346979722 hasConceptScore W346979722C71924100 @default.
- W346979722 hasConceptScore W346979722C7386963 @default.
- W346979722 hasConceptScore W346979722C86803240 @default.
- W346979722 hasConceptScore W346979722C8891405 @default.
- W346979722 hasConceptScore W346979722C89611455 @default.
- W346979722 hasConceptScore W346979722C99454951 @default.
- W346979722 hasIssue "1_Supplement" @default.
- W346979722 hasLocation W3469797221 @default.
- W346979722 hasOpenAccess W346979722 @default.
- W346979722 hasPrimaryLocation W3469797221 @default.
- W346979722 hasRelatedWork W1828948498 @default.
- W346979722 hasRelatedWork W1970327593 @default.
- W346979722 hasRelatedWork W1988517967 @default.
- W346979722 hasRelatedWork W2029056863 @default.
- W346979722 hasRelatedWork W2057739827 @default.
- W346979722 hasRelatedWork W2070922469 @default.
- W346979722 hasRelatedWork W2097988366 @default.
- W346979722 hasRelatedWork W2186316345 @default.
- W346979722 hasRelatedWork W2223919059 @default.
- W346979722 hasRelatedWork W3165452661 @default.
- W346979722 hasVolume "186" @default.
- W346979722 isParatext "false" @default.
- W346979722 isRetracted "false" @default.
- W346979722 magId "346979722" @default.
- W346979722 workType "article" @default.