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- W347096166 abstract "The merR gene product mediates the metal-responsive expression of prokaryotic mercury resistance genes (mer): in the absence of mercury it is a repressor and in the presence of mercury it is an activator of mer gene expression. The corresponding cysteine-containing MerR protein was recently overproduced and shown to be a DNA-binding factor specific for the promoter region of the mer operon. New results from Fe(EDTA)/hydroxyl radical and methylation protection footprinting experiments provide insights into the molecular basis of metal responsive gene regulation in this system. The hydroxyl radical footprint of MerR/DNA interactions consists of two protect areas one overlapping the -10 region and the other overlapping the -35 region of the mer promoter. A third area containing the center of dyad symmetry, 10-11 bp from the other two, was also protected by MerR. Dimethylsulfate experiments indicate MerR protects two guanines, separated on the coding strand by eleven bp, from methylation. These results indicated MerR binds primarily to one face of DNA fragments containing the mer promoter and that it utilizes interactions in the major groove of DNA." @default.
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- W347096166 date "1987-05-01" @default.
- W347096166 modified "2023-09-24" @default.
- W347096166 title "Characterization of the metalloregulatory protein governing mercury resistance genes: specific protein/DNA contacts" @default.
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