Matches in SemOpenAlex for { <https://semopenalex.org/work/W347240911> ?p ?o ?g. }
- W347240911 endingPage "54" @default.
- W347240911 startingPage "39" @default.
- W347240911 abstract "Aquaglyceroporins (GLPs) are integral membrane proteins that facilitate passive movement of water, glycerol and urea across cellular membranes. In this study, GLP-encoding genes were characterized in rainbow smelt (Osmerus mordax mordax), an anadromous teleost that accumulates high glycerol and modest urea levels in plasma and tissues as an adaptive cryoprotectant mechanism in sub-zero temperatures. We report the gene and promoter sequences for two aqp10b paralogs (aqp10ba, aqp10bb) that are 82% identical at the predicted amino acid level, and aqp9b. Aqp10bb and aqp9b have the 6 exon structure common to vertebrate GLPs. Aqp10ba has 8 exons; there are two additional exons at the 5' end, and the promoter sequence is different from aqp10bb. Molecular phylogenetic analysis suggests that the aqp10b paralogs arose from a gene duplication event specific to the smelt lineage. Smelt GLP transcripts are ubiquitously expressed; however, aqp10ba transcripts were highest in kidney, aqp10bb transcripts were highest in kidney, intestine, pyloric caeca and brain, and aqp9b transcripts were highest in spleen, liver, red blood cells and kidney. In cold-temperature challenge experiments, plasma glycerol and urea levels were significantly higher in cold- compared to warm-acclimated smelt; however, GLP transcript levels were generally either significantly lower or remained constant. The exception was significantly higher aqp10ba transcript levels in kidney. High aqp10ba transcripts in smelt kidney that increase significantly in response to cold temperature in congruence with plasma urea suggest that this gene duplicate may have evolved to allow the re-absorption of urea to concomitantly conserve nitrogen and prevent freezing." @default.
- W347240911 created "2016-06-24" @default.
- W347240911 creator A5005183831 @default.
- W347240911 creator A5015830308 @default.
- W347240911 creator A5023645844 @default.
- W347240911 creator A5048818766 @default.
- W347240911 date "2015-09-01" @default.
- W347240911 modified "2023-09-24" @default.
- W347240911 title "Cloning and characterization of aquaglyceroporin genes from rainbow smelt (Osmerus mordax) and transcript expression in response to cold temperature" @default.
- W347240911 cites W1527760132 @default.
- W347240911 cites W170026237 @default.
- W347240911 cites W1944789111 @default.
- W347240911 cites W1961863063 @default.
- W347240911 cites W1964594932 @default.
- W347240911 cites W1965051773 @default.
- W347240911 cites W1966350815 @default.
- W347240911 cites W1969604943 @default.
- W347240911 cites W1977302806 @default.
- W347240911 cites W1979336142 @default.
- W347240911 cites W1983881715 @default.
- W347240911 cites W1989401167 @default.
- W347240911 cites W1994096575 @default.
- W347240911 cites W1995419987 @default.
- W347240911 cites W1997728159 @default.
- W347240911 cites W2006173072 @default.
- W347240911 cites W2009703891 @default.
- W347240911 cites W2017856242 @default.
- W347240911 cites W2029796907 @default.
- W347240911 cites W2037170193 @default.
- W347240911 cites W2041692990 @default.
- W347240911 cites W2048416634 @default.
- W347240911 cites W2053199846 @default.
- W347240911 cites W2054211155 @default.
- W347240911 cites W2058414175 @default.
- W347240911 cites W2060421943 @default.
- W347240911 cites W2061164647 @default.
- W347240911 cites W2065202566 @default.
- W347240911 cites W2074993569 @default.
- W347240911 cites W2076418988 @default.
- W347240911 cites W2079707043 @default.
- W347240911 cites W2083569884 @default.
- W347240911 cites W2083943691 @default.
- W347240911 cites W2084759866 @default.
- W347240911 cites W2085807849 @default.
- W347240911 cites W2088493026 @default.
- W347240911 cites W2094036688 @default.
- W347240911 cites W2098738025 @default.
- W347240911 cites W2098883023 @default.
- W347240911 cites W2099470717 @default.
- W347240911 cites W2106882534 @default.
- W347240911 cites W2107277218 @default.
- W347240911 cites W2108244474 @default.
- W347240911 cites W2109588605 @default.
- W347240911 cites W2112792127 @default.
- W347240911 cites W2120960764 @default.
- W347240911 cites W2130633454 @default.
- W347240911 cites W2133844596 @default.
- W347240911 cites W2135030836 @default.
- W347240911 cites W2141436683 @default.
- W347240911 cites W2142364749 @default.
- W347240911 cites W2143617905 @default.
- W347240911 cites W2152207030 @default.
- W347240911 cites W2152770371 @default.
- W347240911 cites W2159037095 @default.
- W347240911 cites W330756372 @default.
- W347240911 cites W2146743116 @default.
- W347240911 doi "https://doi.org/10.1016/j.cbpb.2015.05.004" @default.
- W347240911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25981700" @default.
- W347240911 hasPublicationYear "2015" @default.
- W347240911 type Work @default.
- W347240911 sameAs 347240911 @default.
- W347240911 citedByCount "7" @default.
- W347240911 countsByYear W3472409112015 @default.
- W347240911 countsByYear W3472409112017 @default.
- W347240911 countsByYear W3472409112019 @default.
- W347240911 countsByYear W3472409112021 @default.
- W347240911 countsByYear W3472409112022 @default.
- W347240911 crossrefType "journal-article" @default.
- W347240911 hasAuthorship W347240911A5005183831 @default.
- W347240911 hasAuthorship W347240911A5015830308 @default.
- W347240911 hasAuthorship W347240911A5023645844 @default.
- W347240911 hasAuthorship W347240911A5048818766 @default.
- W347240911 hasConcept C104317684 @default.
- W347240911 hasConcept C153911025 @default.
- W347240911 hasConcept C2780581811 @default.
- W347240911 hasConcept C2909208804 @default.
- W347240911 hasConcept C36823959 @default.
- W347240911 hasConcept C505870484 @default.
- W347240911 hasConcept C54355233 @default.
- W347240911 hasConcept C55493867 @default.
- W347240911 hasConcept C86803240 @default.
- W347240911 hasConceptScore W347240911C104317684 @default.
- W347240911 hasConceptScore W347240911C153911025 @default.
- W347240911 hasConceptScore W347240911C2780581811 @default.
- W347240911 hasConceptScore W347240911C2909208804 @default.
- W347240911 hasConceptScore W347240911C36823959 @default.
- W347240911 hasConceptScore W347240911C505870484 @default.
- W347240911 hasConceptScore W347240911C54355233 @default.