Matches in SemOpenAlex for { <https://semopenalex.org/work/W34728853> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W34728853 endingPage "5" @default.
- W34728853 startingPage "41" @default.
- W34728853 abstract "The aim of present study was to evaluate the application of a hydrophilic matrix tablet capable of polyion complex (PIC-tablet) to a controlled-release device for highly water-soluble drugs. The PIC-tablet was prepared from a mixture of dextran sulfate and [2-(diethylamino)ethyl] dextran chloride, and diltiazem hydrochloride was used as a model drug. Release tests revealed that the drug release was sustained even in 50% drug loading and was influenced by ionic strength but not by pH in medium. The drug release mechanism was thus investigated from the viewpoint of drug micelle forming property. The micelle forming ability of diltiazem was examined by the conductivity method, and was found to be influenced by ionic strength but not by pH value in accordance with the release tests. The results suggested that the drug's micelle interacted with the polyionic matrix. Further studies were conducted using metoprolol tartrate and thiamine hydrochloride as cationic drugs and sodium cloxacillin and sodium salicylic acid as anionic ones. The release profiles of the micelle-forming drugs metoprolol tartrate and sodium cloxacillin were also suppressed in spite of different solubility or opposite ionic charge from diltiazem hydrochloride. These findings demonstrated that the PIC-tablet is a promising device for oral controlled release delivery of water-soluble drugs with good micelle-forming ability." @default.
- W34728853 created "2016-06-24" @default.
- W34728853 creator A5000540965 @default.
- W34728853 creator A5035882975 @default.
- W34728853 creator A5052606684 @default.
- W34728853 creator A5085789509 @default.
- W34728853 date "2007-01-01" @default.
- W34728853 modified "2023-10-03" @default.
- W34728853 title "Sustained release of highly water-soluble drugs with micelle forming ability from polyionic matrix tablets." @default.
- W34728853 cites W1564120434 @default.
- W34728853 cites W1964600998 @default.
- W34728853 cites W1965779935 @default.
- W34728853 cites W1966225841 @default.
- W34728853 cites W1968478032 @default.
- W34728853 cites W1997041234 @default.
- W34728853 cites W2001882477 @default.
- W34728853 cites W2015858044 @default.
- W34728853 cites W2020575394 @default.
- W34728853 cites W2023248222 @default.
- W34728853 cites W2031826600 @default.
- W34728853 cites W2037228243 @default.
- W34728853 cites W2063475958 @default.
- W34728853 cites W2131715817 @default.
- W34728853 cites W2146883246 @default.
- W34728853 cites W53014880 @default.
- W34728853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17294812" @default.
- W34728853 hasPublicationYear "2007" @default.
- W34728853 type Work @default.
- W34728853 sameAs 34728853 @default.
- W34728853 citedByCount "1" @default.
- W34728853 countsByYear W347288532013 @default.
- W34728853 crossrefType "journal-article" @default.
- W34728853 hasAuthorship W34728853A5000540965 @default.
- W34728853 hasAuthorship W34728853A5035882975 @default.
- W34728853 hasAuthorship W34728853A5052606684 @default.
- W34728853 hasAuthorship W34728853A5085789509 @default.
- W34728853 hasConcept C11268172 @default.
- W34728853 hasConcept C155574463 @default.
- W34728853 hasConcept C164705383 @default.
- W34728853 hasConcept C178790620 @default.
- W34728853 hasConcept C184651966 @default.
- W34728853 hasConcept C185592680 @default.
- W34728853 hasConcept C2776741139 @default.
- W34728853 hasConcept C2781280847 @default.
- W34728853 hasConcept C2909111407 @default.
- W34728853 hasConcept C2909447574 @default.
- W34728853 hasConcept C43617362 @default.
- W34728853 hasConcept C519063684 @default.
- W34728853 hasConcept C71924100 @default.
- W34728853 hasConcept C77281830 @default.
- W34728853 hasConceptScore W34728853C11268172 @default.
- W34728853 hasConceptScore W34728853C155574463 @default.
- W34728853 hasConceptScore W34728853C164705383 @default.
- W34728853 hasConceptScore W34728853C178790620 @default.
- W34728853 hasConceptScore W34728853C184651966 @default.
- W34728853 hasConceptScore W34728853C185592680 @default.
- W34728853 hasConceptScore W34728853C2776741139 @default.
- W34728853 hasConceptScore W34728853C2781280847 @default.
- W34728853 hasConceptScore W34728853C2909111407 @default.
- W34728853 hasConceptScore W34728853C2909447574 @default.
- W34728853 hasConceptScore W34728853C43617362 @default.
- W34728853 hasConceptScore W34728853C519063684 @default.
- W34728853 hasConceptScore W34728853C71924100 @default.
- W34728853 hasConceptScore W34728853C77281830 @default.
- W34728853 hasIssue "1" @default.
- W34728853 hasLocation W347288531 @default.
- W34728853 hasOpenAccess W34728853 @default.
- W34728853 hasPrimaryLocation W347288531 @default.
- W34728853 hasRelatedWork W150301714 @default.
- W34728853 hasRelatedWork W1986580554 @default.
- W34728853 hasRelatedWork W2026966429 @default.
- W34728853 hasRelatedWork W2029709342 @default.
- W34728853 hasRelatedWork W2042334783 @default.
- W34728853 hasRelatedWork W2056735484 @default.
- W34728853 hasRelatedWork W2110560379 @default.
- W34728853 hasRelatedWork W3134451613 @default.
- W34728853 hasRelatedWork W34728853 @default.
- W34728853 hasRelatedWork W2464055990 @default.
- W34728853 hasVolume "62" @default.
- W34728853 isParatext "false" @default.
- W34728853 isRetracted "false" @default.
- W34728853 magId "34728853" @default.
- W34728853 workType "article" @default.