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- W347604911 abstract "Many existing studies have demonstrated that p16 promoter methylation might be correlated with the clinicopathologic features of colorectal cancer (CRC), but individually published results are inconclusive. This meta-analysis aimed to derive a more precise estimation of the relationships between p16 promoter methylation and the clinicopathologic features of CRC. We searched the CISCOM, CINAHL, Web of Science, PubMed, Google Scholar, EBSCO, Cochrane Library, and CBM databases from inception through August 1, 2013. Meta-analysis was performed using the STATA 12.0 software. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated under fixed- or random-effects models. Twenty-seven clinical cohort studies were included with a total of 3311 CRC patients. Our meta-analysis results revealed that p16 promoter methylation was associated with pathological characteristics of CRC (tumor, nodes, metastasis stage: OR=1.55, 95% CI: 1.14–2.13, p=0.006; lymph node metastasis: OR=2.40, 95% CI: 1.37–4.19, p=0.002; histologic grade: OR=2.72, 95% CI: 1.63–4.54, p<0.001; Dukes stage: OR=2.06, 95% CI: 1.57–2.71, p=0.002; tumor size: OR=1.99, 95% CI: 1.03–3.85, p=0.041; location: OR=2.49, 95% CI: 1.95–3.18, p<0.001, respectively). Subgroup analysis by ethnicity suggested that there were also significant correlations between p16 gene promoter methylation and pathological characteristics of CRC among both Caucasian and Asian populations (all p<0.05). Our meta-analysis suggests that promoter methylation of the p16 gene may be strongly correlated with the clinicopathologic features of CRC. Thus, p16 gene promoter methylation may be a potential biomarker for CRC." @default.
- W347604911 created "2016-06-24" @default.
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- W347604911 date "2014-10-01" @default.
- W347604911 modified "2023-10-18" @default.
- W347604911 title "Relationships Betweenp16Gene Promoter Methylation and Clinicopathologic Features of Colorectal Cancer: A Meta-Analysis of 27 Cohort Studies" @default.
- W347604911 cites W1498380447 @default.
- W347604911 cites W1547280020 @default.
- W347604911 cites W1826094137 @default.
- W347604911 cites W1965141556 @default.
- W347604911 cites W1972983414 @default.
- W347604911 cites W1977467011 @default.
- W347604911 cites W1979362779 @default.
- W347604911 cites W1983339712 @default.
- W347604911 cites W1984170705 @default.
- W347604911 cites W1991054314 @default.
- W347604911 cites W2002781770 @default.
- W347604911 cites W2004083740 @default.
- W347604911 cites W2007470097 @default.
- W347604911 cites W2015803329 @default.
- W347604911 cites W2020252642 @default.
- W347604911 cites W2032123085 @default.
- W347604911 cites W2033349234 @default.
- W347604911 cites W2037387911 @default.
- W347604911 cites W2038181620 @default.
- W347604911 cites W2042762321 @default.
- W347604911 cites W2050395200 @default.
- W347604911 cites W2057131883 @default.
- W347604911 cites W2057422906 @default.
- W347604911 cites W2062854830 @default.
- W347604911 cites W2063618232 @default.
- W347604911 cites W2064915317 @default.
- W347604911 cites W2072500364 @default.
- W347604911 cites W2075358688 @default.
- W347604911 cites W2077538717 @default.
- W347604911 cites W2080337685 @default.
- W347604911 cites W2084662944 @default.
- W347604911 cites W2085852125 @default.
- W347604911 cites W2087496317 @default.
- W347604911 cites W2089255658 @default.
- W347604911 cites W2092670649 @default.
- W347604911 cites W2095520734 @default.
- W347604911 cites W2102271627 @default.
- W347604911 cites W2103524011 @default.
- W347604911 cites W2105428856 @default.
- W347604911 cites W2106613407 @default.
- W347604911 cites W2106787323 @default.
- W347604911 cites W2107852315 @default.
- W347604911 cites W2114486584 @default.
- W347604911 cites W2116475791 @default.
- W347604911 cites W2116581671 @default.
- W347604911 cites W2116817886 @default.
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- W347604911 cites W2120483508 @default.
- W347604911 cites W2122580718 @default.
- W347604911 cites W2127840259 @default.
- W347604911 cites W2130396542 @default.
- W347604911 cites W2134852288 @default.
- W347604911 cites W2135025419 @default.
- W347604911 cites W2135855165 @default.
- W347604911 cites W2140383748 @default.
- W347604911 cites W2141137133 @default.
- W347604911 cites W2142579389 @default.
- W347604911 cites W2151037856 @default.
- W347604911 cites W2151415279 @default.
- W347604911 cites W2164467861 @default.
- W347604911 cites W2166801400 @default.
- W347604911 cites W2169858868 @default.
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- W347604911 cites W2186822725 @default.
- W347604911 cites W2187886502 @default.
- W347604911 cites W2187938013 @default.
- W347604911 cites W226345221 @default.
- W347604911 cites W2411701108 @default.
- W347604911 cites W2428680925 @default.
- W347604911 cites W2470517880 @default.
- W347604911 cites W345702292 @default.
- W347604911 doi "https://doi.org/10.1089/dna.2013.2253" @default.
- W347604911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24979649" @default.
- W347604911 hasPublicationYear "2014" @default.
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