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- W3477976 abstract "Histone modification is the key event in epigenetic regulation of gene expression in most eukaryotes. Plants, fungi, and vertebrates have machineries for DNA methylation as an additional layer of epigenetic modification, and the presence of CHH and CHG (H = A, T, or C) methylation sites are characteristics of plants. In Arabidopsis thaliana, both CHH and CHG methylation sites are enriched with sequences related to transposons in heterochromatin regions, and the RNA-directed DNA methylation pathway plays a major role in asymmetric cytosine (CHH) methylation. Heterochromatin regions are also rich in dimethylated histone H3 lysine 9 (H3K9me2) – a histone mark of inert chromatin. Although enzymes transferring methyl groups to DNA or H3K9 have been identified, mechanisms linking these two methylation steps specifically to inert chromatin are obscure. In this chapter, we review characteristics of the machineries governing DNA methylation and histone modification in A. thaliana and discuss the possible interplay between these two epigenetic marks in relation to suppression of non coding RNA production." @default.
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- W3477976 date "2011-01-01" @default.
- W3477976 modified "2023-10-01" @default.
- W3477976 title "Mechanisms Linking Cytosine Methylation to Histone Modification in Arabidopsis thaliana" @default.
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- W3477976 doi "https://doi.org/10.1007/978-3-642-19454-2_15" @default.
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