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- W347857349 abstract "Abstract : Results of earlier investigators indicate that radiomesis is mediated by some humoral agent(s). Peptides are likely candiates since they exert a number of biological effects and are released from storage sites by various stimuli, including radiation. Peptides at various concentrations were injected singly intravenously into conscious dogs, and the dog's emetic response was observed. Of the peptides tested, neurotensin, angiotensin II, vasopressin, oxytocin, and TRH produced consistent emetic responses. Inhibition of drug-induced emesis was studied both centrally (chlorpromazine) and peripherally (domperidone) acting dopamine antagonists. Results indicate inhibition by chlorpromazine, which crosses the blood brain barrier, but only partial blockade by domperidone, which does not cross the blood brain barrier. Preliminary studies were conduted attempting to characterize types of receptors on area postrema neurons. Single-cell recordings from these neurons, challenged by iontophoretic administration of various neurotransmitters, show stimulation by glutamic acid and serotonin and inhibiiton by norepinephrine." @default.
- W347857349 created "2016-06-24" @default.
- W347857349 creator A5074232978 @default.
- W347857349 date "1982-09-01" @default.
- W347857349 modified "2023-09-27" @default.
- W347857349 title "Peptideinduced Emesis in Dogs: Possible Relevance to Radiation-Induced Emesis." @default.
- W347857349 doi "https://doi.org/10.21236/ada120667" @default.
- W347857349 hasPublicationYear "1982" @default.
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