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- W348157143 abstract "Abstract Salmonella vaccine vector expressing enterotoxigenic E. coli CFA/I fimbriae has been shown to protect against EAE and CIA. Vaccine-induced CD25+CD4+ and CD25-CD4+ T cells were potent against CIA, and such protection was reversed by anti-TGF-β treatment. We demonstrate, Salmonella-CFA/I-stimulated CD39+CD4+ T cells correlate with accelerated hydrolysis of extracellular ATP, a mechanism of immune suppression. Since vaccine-induced FoxP3-CD39+CD25-CD4+ T cells are shown to be the source of TGF-β, we hypothesized TGF-β could be important in regulating CD39 expression and consequential suppression of CIA. Salmonella-CFA/I-induced CD4+ T cells featured enhanced activation of cAMP-response element-binding protein (CREB), essential for transcriptional regulation of CD39. CREB phosphorylation was suppressed by in vivo treatment of Salmonella-CFA/I-immunized mice with anti-TGF-β mAb. Decrease in phosphorylated CREB correlated with 2-fold less CD39+CD4+ T cells. Although Salmonella-CFA/I-induced FoxP3-CD4+ T cells protected against CIA, as well as CD39+CD4+ T cells upon adoptive transfer, subsequent FACS analysis of recipients’ CD4+ T cells revealed conversion of FoxP3-(GFP-) cells to FoxP3+. Thus, Salmonella-CFA/I stimulates TGF-β production by FoxP3-CD39+CD4+ T cells, promoting the CREB-dependent expansion of CD39+CD4+ T cells becoming regulatory FoxP3+CD4+ T cells. Supported by AT004312." @default.
- W348157143 created "2016-06-24" @default.
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- W348157143 date "2011-04-01" @default.
- W348157143 modified "2023-09-25" @default.
- W348157143 title "Colonization factor antigen I expression by <i>Salmonella</i> induces CREB-dependent stimulation of CD39+CD4+ T cells responsible for protection against collagen-induced arthritis (107.5)" @default.
- W348157143 doi "https://doi.org/10.4049/jimmunol.186.supp.107.5" @default.
- W348157143 hasPublicationYear "2011" @default.
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