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• W348516901 abstract "Significant paravalvular leakage after transcatheter aortic valve implantation (TAVI) correlates with increased morbidity and mortality, but adverse consequences of trivial paravalvular leakage have stimulated few investigations. Using a unique method distinctly different from other diagnostic approaches, we previously reported elevated backflow velocities of short duration (transients) in mechanical valve closure. In this study, similar transients were found in a transcatheter valve paravalvular leakage avatar.Paravalvular leakage rate (zero to 58 mL/second) and aortic valve incompetence (volumetric back flow/forward flow; zero to 32%) were made adjustable using a mock transcatheter aortic valve device and tested in quasi-steady and pulsatile flow test systems. Projected dynamic valve area (PDVA) from the back illuminated mock transcatheter aortic valve device was measured and regional backflow velocities were derived by dividing volumetric flow rate by the PDVA over the open and closing valve phase and the total closed valve area derived from backflow leakage.Aortic incompetence from 1-32% generated negative backflow transients from 8 to 267 meters/second, a range not dissimilar to that measured in mechanical valves with zero paravalvular leakage. Optimal paravalvular leakage was identified; not too small generating high backflow transients, not too large considering volume overload and cardiac energy loss caused by defective valve behavior and fluid motion.Thrombogenic potential of transcatheter aortic valves with trivial aortic incompetence and high magnitude regional backflow velocity transients was comparable to mechanical valves. This may have relevance to stroke rate, asymptomatic microembolic episodes and indications for anticoagulation therapy after transcatheter valve insertion." @default.
• W348516901 created "2016-06-24" @default.
• W348516901 creator A5025978822 @default.
• W348516901 creator A5053579253 @default.
• W348516901 date "2014-05-01" @default.
• W348516901 modified "2023-09-23" @default.
• W348516901 title "Thrombogenic potential of transcatheter aortic valve implantation with trivial paravalvular leakage." @default.
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• W348516901 doi "https://doi.org/10.3978/j.issn.2305-5839.2014.05.04" @default.
• W348516901 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4200687" @default.
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