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- W34955570 abstract "AbstractBiological effects of uric acid, generated in the human body either from food or resulting from the purine degradation pathway via xanthine oxidoreductase, are extremely pleiotropic. They are paradoxically opposing under different experimental conditions. Some of these effects are beneficial and some of them are deleterious. The key feature of uric acid is the ability to be either an antioxidant or pro-oxidant depending on a variety of factors. The complexity of the urate chemistry, including its ability to quench or form various radicals, is a crucial component of the mechanisms underlying the ability of uric acid to induce opposing biological effects. In addition, uric acid is a powerful signaling molecule that can affect intracellular signal transduction, leading to oxidant production via nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and expression of proinflammatory mediators. Beneficial antioxidant effects are manifested in the protection of endothelial cells from external oxidative stress and protection of the central nervous system from oxidative damage in several conditions. Detrimental pro-oxidative effects of uric acid are associated with the metabolic syndrome and cardiovascular and renal diseases.KeywordsXanthine oxidoreductaseMetabolic syndromeEndothelium" @default.
- W34955570 created "2016-06-24" @default.
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- W34955570 creator A5023766873 @default.
- W34955570 creator A5077968566 @default.
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- W34955570 date "2010-11-22" @default.
- W34955570 modified "2023-10-17" @default.
- W34955570 title "Uric Acid and Oxidative Stress" @default.
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