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• W349568703 abstract "may be more suitable for analogy with human populations. The present communication concerns tests of caffeine for its ability to induce translocations in mouse chromosomes. Caff, eine (trimethylxanthi ne) was selected for test since it is an active constituent of tea, coffee, and cocoa and has been shown to have mutagenic properties in a variety of other organisms (KIttLMAN and LWVAN 1949; NOVICK and SZlLAR]) ]951; GLASS and NOVICK 1959; ANDREW 1959). The results indicate that caffeine is only weakly mutagenic in mice, for only two possible translocations were detected. An effect upon the fertility of the treated animals was, however, observed. Methods and materials GOLDSTEIN (personal communication) has shown that C57/DBA mice will accept caffeine in their drinking water up to a concentration of 3 gms/litre and will maintain weight apparently indefinitely. He suggested that this dose would be the most suitable for genetic experiments. Preliminary tests with the strain of mice used in the present experiment were in agreement with this suggestion. 3 gins. caffeine per lltre of drinking water was the highest dose that could be administered without noticeably affecting the health of the animals. Fourteen inbred (JU) males were therefore given 0.3% solutions of caffeine as their drinking water and this was renewed each week. Treatment was continued for three months to ensure that the earliest spermatogonia were subjected to the caffeine administration for some time. At the end of this period each male was placed with three virgin females from a randombred stock (Q) and left for six weeks. The females were examined each morning for vaginal plugs and those which had copulated were removed and replaced by new virgin females. The mated females were placed in separate cages and allowed to go to term when the littersizes were scored. All the offspring were kept until three weeks old, at which time they were examined for morphological abnol~nalgies, and the daughters then discarded. The sons were kept until at ]east six weeks old when they were tested for the possession of a translocation. Preliminary screening was done by fertility tests. Each male was placed with two virgin Q stock females and the litter sizes were scored at birth. Those males which had an average litter-size of less than eight among the litters of both females were suspected of being heterozygous for a translocation. Such males were retested and a cytological examination of the testes was carried out if the litter size remained low. Two cytological techniques were employed: firstly, preparations from one testis were made by the method of WELSHONS et a]. (]962) and secondly, if further analysis was required, preparations from the other testis were made by the method of SLIZYNSKI (AuS.RBAC]~ and SLIZYNSKI 1956). The existence of nineteen instead of twenty separate elements seen in at least eight metaphase plates of the first meiotic division was the criterion used to indicate the presence of a translocation." @default.
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• W349568703 date "1962-01-01" @default.
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• W349568703 title "From M. R. C. Mutagenesis Research Group, Institute of Animal Genetics, Edinburgh, 9 GENETICAL EFFECTS OF CAFFEINE IN MICE" @default.
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