Matches in SemOpenAlex for { <https://semopenalex.org/work/W34970025> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W34970025 endingPage "8" @default.
- W34970025 startingPage "S33" @default.
- W34970025 abstract "The hypothesis that follicle-stimulating hormone (FSH) signaling contributes to the progression of androgen-independent prostate cancer (AIPC) is supported by preclinical evidence. Therefore, abarelix, a gonadotropin-releasing hormone antagonist that suppresses circulating FSH more effectively than standard hormone therapies, would be expected to reduce FSH without altering testosterone, thereby testing the hypothesis that circulating FSH supports the progression of AIPC. The authors tested abarelix on 2 groups of men with early AIPC: 1 group had undergone luteinizing hormone-releasing hormone agonist therapy and the other had undergone orchiectomy. Although there was no confirmed response in either group, the investigators found the time to progression, fraction of patients progression-free at the end of therapy, and fraction of patients with confirmed prostate-specific antigen reductions less than 50% were all higher in the orchiectomy-treated patients. This hypothesis-generating observation has led to a phase I trial to determine whether an escalation in the dosage of abarelix is safe and will produce more complete suppression of FSH." @default.
- W34970025 created "2016-06-24" @default.
- W34970025 creator A5048477205 @default.
- W34970025 date "2004-01-01" @default.
- W34970025 modified "2023-09-23" @default.
- W34970025 title "Experimental use of GnRH antagonists as second-line hormonal therapy." @default.
- W34970025 cites W1574285508 @default.
- W34970025 cites W164068869 @default.
- W34970025 cites W1964370832 @default.
- W34970025 cites W1966593350 @default.
- W34970025 cites W1970413305 @default.
- W34970025 cites W1978972640 @default.
- W34970025 cites W1982138700 @default.
- W34970025 cites W1996480361 @default.
- W34970025 cites W1999505630 @default.
- W34970025 cites W1999707905 @default.
- W34970025 cites W2007893924 @default.
- W34970025 cites W2012220883 @default.
- W34970025 cites W2026723408 @default.
- W34970025 cites W2036495484 @default.
- W34970025 cites W2040196584 @default.
- W34970025 cites W2081679563 @default.
- W34970025 cites W2120306129 @default.
- W34970025 cites W2139248078 @default.
- W34970025 cites W2139495612 @default.
- W34970025 cites W2155679349 @default.
- W34970025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1472888" @default.
- W34970025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16985935" @default.
- W34970025 hasPublicationYear "2004" @default.
- W34970025 type Work @default.
- W34970025 sameAs 34970025 @default.
- W34970025 citedByCount "4" @default.
- W34970025 countsByYear W349700252015 @default.
- W34970025 countsByYear W349700252023 @default.
- W34970025 crossrefType "journal-article" @default.
- W34970025 hasAuthorship W34970025A5048477205 @default.
- W34970025 hasConcept C121608353 @default.
- W34970025 hasConcept C126322002 @default.
- W34970025 hasConcept C134018914 @default.
- W34970025 hasConcept C143998085 @default.
- W34970025 hasConcept C170493617 @default.
- W34970025 hasConcept C2776235491 @default.
- W34970025 hasConcept C2777886879 @default.
- W34970025 hasConcept C2777899217 @default.
- W34970025 hasConcept C2778575703 @default.
- W34970025 hasConcept C2778938600 @default.
- W34970025 hasConcept C2779279165 @default.
- W34970025 hasConcept C2779279991 @default.
- W34970025 hasConcept C2780192828 @default.
- W34970025 hasConcept C2781440318 @default.
- W34970025 hasConcept C46699223 @default.
- W34970025 hasConcept C71315377 @default.
- W34970025 hasConcept C71924100 @default.
- W34970025 hasConceptScore W34970025C121608353 @default.
- W34970025 hasConceptScore W34970025C126322002 @default.
- W34970025 hasConceptScore W34970025C134018914 @default.
- W34970025 hasConceptScore W34970025C143998085 @default.
- W34970025 hasConceptScore W34970025C170493617 @default.
- W34970025 hasConceptScore W34970025C2776235491 @default.
- W34970025 hasConceptScore W34970025C2777886879 @default.
- W34970025 hasConceptScore W34970025C2777899217 @default.
- W34970025 hasConceptScore W34970025C2778575703 @default.
- W34970025 hasConceptScore W34970025C2778938600 @default.
- W34970025 hasConceptScore W34970025C2779279165 @default.
- W34970025 hasConceptScore W34970025C2779279991 @default.
- W34970025 hasConceptScore W34970025C2780192828 @default.
- W34970025 hasConceptScore W34970025C2781440318 @default.
- W34970025 hasConceptScore W34970025C46699223 @default.
- W34970025 hasConceptScore W34970025C71315377 @default.
- W34970025 hasConceptScore W34970025C71924100 @default.
- W34970025 hasLocation W349700251 @default.
- W34970025 hasOpenAccess W34970025 @default.
- W34970025 hasPrimaryLocation W349700251 @default.
- W34970025 hasRelatedWork W1924774303 @default.
- W34970025 hasRelatedWork W1981468192 @default.
- W34970025 hasRelatedWork W1991634850 @default.
- W34970025 hasRelatedWork W2005718116 @default.
- W34970025 hasRelatedWork W2030703350 @default.
- W34970025 hasRelatedWork W2062421000 @default.
- W34970025 hasRelatedWork W2121299924 @default.
- W34970025 hasRelatedWork W2346786184 @default.
- W34970025 hasRelatedWork W4241378879 @default.
- W34970025 hasRelatedWork W2411910748 @default.
- W34970025 hasVolume "6 Suppl 7" @default.
- W34970025 isParatext "false" @default.
- W34970025 isRetracted "false" @default.
- W34970025 magId "34970025" @default.
- W34970025 workType "article" @default.