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• W34975090 abstract "Interactions between cells and extracellular matrix (ECM) are critical to the biological processes that take place in tissue such as cartilage. These processes include cell adhesion, growth, differentiation, migration, and matrix synthesis and degradation. The cell receptors playing a central role in cellular attachment to ECM are members of integrin family of heterodimeric transmembrane glycoproteins and some other cell membrane proteins: recently we have demonstrated that the cell membrane-bound peptidases CD 10 and CD26 are expressed on human articular chondrocytes and that their expression decreases with the worsening of osteoarthritis. Unpublished observations about the intracellular levels of substance P, met-Enkephalin, GRP and IL 10, carried out in our lab, seem to confirm the hypothesis that the “inside-out signaling” mediated by adhesion molecules, cooperates with a network of growth factors and cytokines, locally produced and carried through the ECM.Our studies provide evidence that chondrocytes are supplied with an ample system of receptors widely interacting with an environmental signaling system and with the ECM that may act as “solid state modulator” of their metabolic activity. Final result of these interactions is the homeostatic balance or, alternatively, in case of disturbing circumstances, the metabolic alteration heading to the typical changes of osteoarthritis.KeywordsArticular CartilageArticular ChondrocytesHuman Articular ChondrocytesCellular AttachmentHomeostatic BalanceThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
• W34975090 created "2016-06-24" @default.
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• W34975090 date "1999-01-01" @default.
• W34975090 modified "2023-09-27" @default.
• W34975090 title "Chondrocytes-ECM Interactions in Human Osteoarthritis" @default.
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• W34975090 doi "https://doi.org/10.1007/978-1-4615-4857-7_62" @default.
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