Matches in SemOpenAlex for { <https://semopenalex.org/work/W34985502> ?p ?o ?g. }
- W34985502 endingPage "9" @default.
- W34985502 startingPage "2713" @default.
- W34985502 abstract "To determine if the purine vasodilator adenosine participates in mediating autoregulatory dilations of the retinal microcirculation in vivo.The retinal microcirculation of isoflurane-anesthetized newborn pigs was observed by videomicroscopy (x310). Systemic hypoxia (PaO2 = 24 +/- 1 mm Hg; n = 8) or hemorrhagic hypotension (MABP = 41 +/- 1 mm Hg; n = 5) was induced, and the effect of intravitreal microsuffusion of 0.4 nmol of the adenosine receptor antagonist 8-sulfophenyltheophylline (8SPT) on retinal arteriolar dilations resulting from these stimuli were measured. The effect of potentiation of endogenous interstitial adenosine concentrations with 0.2 nmol 4-nitrobenzyl-6-thioinosine (NBTI) on the response to hypotension (MABP = 43 +/- 2 mm Hg; n = 4) was also determined.The significant vasodilatative response of the retinal arterioles to systemic hypoxia (36 +/- 8% increase in diameter above baseline; P = 0.0012) was attenuated 55% (P < 0.0001) by the adenosine antagonist 8SPT. Similarly, the significant arteriolar vasodilation induced by systemic hypotension (29 +/- 3% increase in diameter; P < 0.0001) was inhibited 76% by 8SPT (P = 0.0002). When adenosine reuptake was inhibited with NBTI, the arteriolar dilation induced by hypotension (32 +/- 5% increase in diameter; P = 0.0234) was potentiated 100% (P = 0.0117).Our finding that inhibition or potentiation of endogenous adenosine action uniquely affected retinal arteriolar dilatative responses to hypoxia and hypotension suggests that adenosine is a key participant in mediating autoregulatory adjustments in retinal blood flow in the eye of the newborn." @default.
- W34985502 created "2016-06-24" @default.
- W34985502 creator A5026257559 @default.
- W34985502 creator A5079864309 @default.
- W34985502 date "1993-08-01" @default.
- W34985502 modified "2023-09-24" @default.
- W34985502 title "Adenosine-mediated autoregulation of retinal arteriolar tone in the piglet." @default.
- W34985502 cites W130404104 @default.
- W34985502 cites W1576343099 @default.
- W34985502 cites W167784803 @default.
- W34985502 cites W1983550129 @default.
- W34985502 cites W2008591928 @default.
- W34985502 cites W2018331825 @default.
- W34985502 cites W2026978309 @default.
- W34985502 cites W2027593174 @default.
- W34985502 cites W2031927748 @default.
- W34985502 cites W2048944780 @default.
- W34985502 cites W2049695644 @default.
- W34985502 cites W2059595333 @default.
- W34985502 cites W2062639625 @default.
- W34985502 cites W2075387602 @default.
- W34985502 cites W2076948208 @default.
- W34985502 cites W2083044764 @default.
- W34985502 cites W2093063200 @default.
- W34985502 cites W2112479900 @default.
- W34985502 cites W2118361768 @default.
- W34985502 cites W2149212141 @default.
- W34985502 cites W2179123097 @default.
- W34985502 cites W36239905 @default.
- W34985502 cites W2101523804 @default.
- W34985502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8344793" @default.
- W34985502 hasPublicationYear "1993" @default.
- W34985502 type Work @default.
- W34985502 sameAs 34985502 @default.
- W34985502 citedByCount "27" @default.
- W34985502 countsByYear W349855022012 @default.
- W34985502 countsByYear W349855022014 @default.
- W34985502 countsByYear W349855022015 @default.
- W34985502 countsByYear W349855022016 @default.
- W34985502 countsByYear W349855022017 @default.
- W34985502 countsByYear W349855022018 @default.
- W34985502 countsByYear W349855022020 @default.
- W34985502 crossrefType "journal-article" @default.
- W34985502 hasAuthorship W34985502A5026257559 @default.
- W34985502 hasAuthorship W34985502A5079864309 @default.
- W34985502 hasConcept C118487528 @default.
- W34985502 hasConcept C120770815 @default.
- W34985502 hasConcept C126322002 @default.
- W34985502 hasConcept C12722491 @default.
- W34985502 hasConcept C134018914 @default.
- W34985502 hasConcept C170493617 @default.
- W34985502 hasConcept C178790620 @default.
- W34985502 hasConcept C185592680 @default.
- W34985502 hasConcept C2776991684 @default.
- W34985502 hasConcept C2778938600 @default.
- W34985502 hasConcept C2779482390 @default.
- W34985502 hasConcept C2780634109 @default.
- W34985502 hasConcept C2780827179 @default.
- W34985502 hasConcept C42219234 @default.
- W34985502 hasConcept C540031477 @default.
- W34985502 hasConcept C67907053 @default.
- W34985502 hasConcept C71924100 @default.
- W34985502 hasConcept C7836513 @default.
- W34985502 hasConceptScore W34985502C118487528 @default.
- W34985502 hasConceptScore W34985502C120770815 @default.
- W34985502 hasConceptScore W34985502C126322002 @default.
- W34985502 hasConceptScore W34985502C12722491 @default.
- W34985502 hasConceptScore W34985502C134018914 @default.
- W34985502 hasConceptScore W34985502C170493617 @default.
- W34985502 hasConceptScore W34985502C178790620 @default.
- W34985502 hasConceptScore W34985502C185592680 @default.
- W34985502 hasConceptScore W34985502C2776991684 @default.
- W34985502 hasConceptScore W34985502C2778938600 @default.
- W34985502 hasConceptScore W34985502C2779482390 @default.
- W34985502 hasConceptScore W34985502C2780634109 @default.
- W34985502 hasConceptScore W34985502C2780827179 @default.
- W34985502 hasConceptScore W34985502C42219234 @default.
- W34985502 hasConceptScore W34985502C540031477 @default.
- W34985502 hasConceptScore W34985502C67907053 @default.
- W34985502 hasConceptScore W34985502C71924100 @default.
- W34985502 hasConceptScore W34985502C7836513 @default.
- W34985502 hasIssue "9" @default.
- W34985502 hasLocation W349855021 @default.
- W34985502 hasOpenAccess W34985502 @default.
- W34985502 hasPrimaryLocation W349855021 @default.
- W34985502 hasRelatedWork W1965035435 @default.
- W34985502 hasRelatedWork W1970152920 @default.
- W34985502 hasRelatedWork W1978342765 @default.
- W34985502 hasRelatedWork W2017033017 @default.
- W34985502 hasRelatedWork W2038386297 @default.
- W34985502 hasRelatedWork W2056237732 @default.
- W34985502 hasRelatedWork W2058273987 @default.
- W34985502 hasRelatedWork W2083646371 @default.
- W34985502 hasRelatedWork W28763460 @default.
- W34985502 hasRelatedWork W34985502 @default.
- W34985502 hasVolume "34" @default.
- W34985502 isParatext "false" @default.
- W34985502 isRetracted "false" @default.