Matches in SemOpenAlex for { <https://semopenalex.org/work/W350026092> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W350026092 abstract "Diabetes mellitus (DM) is a metabolic disorder manifested by abnormallyhigh levels of blood glucose, resulting in hyperglicemia that affected on the oralcavity, leading to periodontitis. The junctional epithelium (JE) is the epithelialcomponent of the dento-gingival unit that is in contact with the tooth surface,located between a non-renewable tooth surface and gingival connective tissue. Inaddition, apoptosis is a highly regulated form of programmed cell death that canbe triggered by various signals and is characterized by well-defined morphologicchanges and biochemical features. Caspase-3 is involved in the underlyingmechanisms of apoptosis and the activation of caspase-3 is considered to be thefinal step in many apoptosis pathways. Hence, the aim of this study was toinvestigate the effect of diabetes mellitus (DM) on the expression of caspase-3and the thickness of JE.Sixteen male Sprague-Dawley rats were used, and divided equally into twogroups: Group I, as diabetic groups that injected intraperitoneal by streptozotocin(STZ). Group II, as negative control groups. Measurement of blood glucose levelswere analyzed before and at 2, 4 weeks after STZ injection. In addition, JEthickness and expression of caspase-3 were examined too after 2 and 4 weeks. JEwas stained by hematoxylin eosin (H&E) staining for thickness measurement andthe immunohistochemistry by using anti-caspase-3 antibody for caspase-3expression measurement, and examined under light microscope. The results wereanalyzed by Two Ways Anova and Least Significant Difference (LSD) tests.The results of the present study were showed that decrease of JE thicknessand increase of caspase-3 expression followed with increasing of the diabeticduration. Thus, there were significant different in the thickness of JE between allgroups, except in control groups after 2 and 4 weeks and caspase-3 expression ofJE between all groups, except in control groups after 2 and 4 weeks, and diabeticgroups after 2 and 4 weeks (P > 0.05). It can be concluded that diabetes mellitus(DM) affected on the thickness and caspase-3 expression of JE and suggested thathigh expression of caspase-3 were associated with the diabetes-induced apoptoticcell death resulting in reduction of JE thickness." @default.
- W350026092 created "2016-06-24" @default.
- W350026092 creator A5060488602 @default.
- W350026092 date "2011-01-01" @default.
- W350026092 modified "2023-09-27" @default.
- W350026092 title "THE EFFECT OF DIABETES MELLITUS ON THETHICKNESS OF GINGIVAL JUNCTIONAL EPITHELIUM(Study in the Experiment of Caspase-3)" @default.
- W350026092 hasPublicationYear "2011" @default.
- W350026092 type Work @default.
- W350026092 sameAs 350026092 @default.
- W350026092 citedByCount "0" @default.
- W350026092 crossrefType "dissertation" @default.
- W350026092 hasAuthorship W350026092A5060488602 @default.
- W350026092 hasConcept C12519072 @default.
- W350026092 hasConcept C125473707 @default.
- W350026092 hasConcept C126322002 @default.
- W350026092 hasConcept C134018914 @default.
- W350026092 hasConcept C142724271 @default.
- W350026092 hasConcept C184954099 @default.
- W350026092 hasConcept C185592680 @default.
- W350026092 hasConcept C190283241 @default.
- W350026092 hasConcept C204232928 @default.
- W350026092 hasConcept C2779280383 @default.
- W350026092 hasConcept C2780159080 @default.
- W350026092 hasConcept C2780385504 @default.
- W350026092 hasConcept C31573885 @default.
- W350026092 hasConcept C518705261 @default.
- W350026092 hasConcept C529295009 @default.
- W350026092 hasConcept C55493867 @default.
- W350026092 hasConcept C555293320 @default.
- W350026092 hasConcept C71924100 @default.
- W350026092 hasConcept C98424977 @default.
- W350026092 hasConceptScore W350026092C12519072 @default.
- W350026092 hasConceptScore W350026092C125473707 @default.
- W350026092 hasConceptScore W350026092C126322002 @default.
- W350026092 hasConceptScore W350026092C134018914 @default.
- W350026092 hasConceptScore W350026092C142724271 @default.
- W350026092 hasConceptScore W350026092C184954099 @default.
- W350026092 hasConceptScore W350026092C185592680 @default.
- W350026092 hasConceptScore W350026092C190283241 @default.
- W350026092 hasConceptScore W350026092C204232928 @default.
- W350026092 hasConceptScore W350026092C2779280383 @default.
- W350026092 hasConceptScore W350026092C2780159080 @default.
- W350026092 hasConceptScore W350026092C2780385504 @default.
- W350026092 hasConceptScore W350026092C31573885 @default.
- W350026092 hasConceptScore W350026092C518705261 @default.
- W350026092 hasConceptScore W350026092C529295009 @default.
- W350026092 hasConceptScore W350026092C55493867 @default.
- W350026092 hasConceptScore W350026092C555293320 @default.
- W350026092 hasConceptScore W350026092C71924100 @default.
- W350026092 hasConceptScore W350026092C98424977 @default.
- W350026092 hasLocation W3500260921 @default.
- W350026092 hasOpenAccess W350026092 @default.
- W350026092 hasPrimaryLocation W3500260921 @default.
- W350026092 hasRelatedWork W2036983746 @default.
- W350026092 hasRelatedWork W2060376930 @default.
- W350026092 hasRelatedWork W2160369501 @default.
- W350026092 hasRelatedWork W2347358387 @default.
- W350026092 hasRelatedWork W2356478238 @default.
- W350026092 hasRelatedWork W2356619753 @default.
- W350026092 hasRelatedWork W2358443968 @default.
- W350026092 hasRelatedWork W2364314025 @default.
- W350026092 hasRelatedWork W2367935484 @default.
- W350026092 hasRelatedWork W2369244502 @default.
- W350026092 hasRelatedWork W2373326646 @default.
- W350026092 hasRelatedWork W2377275846 @default.
- W350026092 hasRelatedWork W2379558179 @default.
- W350026092 hasRelatedWork W2383598866 @default.
- W350026092 hasRelatedWork W2384030302 @default.
- W350026092 hasRelatedWork W2387725343 @default.
- W350026092 hasRelatedWork W2390726967 @default.
- W350026092 hasRelatedWork W2415345319 @default.
- W350026092 hasRelatedWork W3029259265 @default.
- W350026092 hasRelatedWork W3030900797 @default.
- W350026092 isParatext "false" @default.
- W350026092 isRetracted "false" @default.
- W350026092 magId "350026092" @default.
- W350026092 workType "dissertation" @default.