FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W350432274> ?p ?o ?g. }

• W350432274 endingPage "218" @default.
• W350432274 startingPage "209" @default.
• W350432274 abstract "We have previously found that recombinant human interferon-alpha 2A (rHu-IFN-alpha 2A) inhibits hypothalamo-pituitary-adrenocortical (HPA) axis activity following both peripheral and central administration. This effect is antagonized by mu-opioid receptor antagonists, suggesting transduction by this subtype of opioid receptors. We have now demonstrated that this effect is also observed with hybrid rHu-IFN-alpha A/D, rat kidney fibroblast-derived IFN-alpha, and recombinant rat IFN-alpha preparations. The inhibitory effects on HPA activity were observed after intraperitoneal (i.p.) injections of rHu-IFN-alpha2A(10(03)U), rHu-IFN-alpha A/D (10(4)U), and of Rat-IFN-alpha (1-10U). Similar effects were observed with intracerebroventricular (i.c.v.) administration of all four IFN-alpha preparations. No increases in plasma corticosterone concentrations were observed with doses of rHu-IFN-alpha A/D up to 10(6)U (i.p.) or 7x10(5)U (i.c.v.), but increases were found following i.c.v. administration of high doses of Rat-IFN-alpha (10(3) and 5x10(3)U). The inhibitory effects of all of the IFN-alpha preparations tested were antagonized by naloxone, but the stimulatory effects of 5x10(3)U Rat-IFN-alpha were not. Injections of rHu-IFN-alpha 2A(10(4)U, i.p.) to urethane-anesthetized rats decreased the electrical activity of the majority of hypothalamic paraventricular nucleus (PVN) neurons tested, including putative corticotropin-releasing factor-(CRF)-secreting neurons antidromically identified as projecting to the median eminence. Similarly, iontophoretic application of rHu-IFN-alpha 2A decreased the electrical activity of such cells. These electrophysiological data suggest that the decreases in HPA activity evoked by IFN-alpha are mediated, at least in part, by a rapid inhibitory effect at the level of the corticotropin-releasing factor-secreting neurons." @default.
• W350432274 created "2016-06-24" @default.
• W350432274 creator A5051622981 @default.
• W350432274 date "1995-01-01" @default.
• W350432274 modified "2023-09-25" @default.
• W350432274 title "Neuroendocrine Effects of Interferon-α in the Rat" @default.
• W350432274 cites W1566302510 @default.
• W350432274 cites W158034811 @default.
• W350432274 cites W1937560614 @default.
• W350432274 cites W1966656379 @default.
• W350432274 cites W1983489695 @default.
• W350432274 cites W1983894299 @default.
• W350432274 cites W1986140286 @default.
• W350432274 cites W1988657646 @default.
• W350432274 cites W1993292827 @default.
• W350432274 cites W1995240439 @default.
• W350432274 cites W1995893892 @default.
• W350432274 cites W2007618665 @default.
• W350432274 cites W2014837971 @default.
• W350432274 cites W2018073475 @default.
• W350432274 cites W2026676527 @default.
• W350432274 cites W2035072797 @default.
• W350432274 cites W2036764069 @default.
• W350432274 cites W2037046526 @default.
• W350432274 cites W2043141482 @default.
• W350432274 cites W2052069735 @default.
• W350432274 cites W2062004514 @default.
• W350432274 cites W2069784578 @default.
• W350432274 cites W2077601302 @default.
• W350432274 cites W2083596267 @default.
• W350432274 cites W2090857040 @default.
• W350432274 cites W2091628983 @default.
• W350432274 cites W2093896551 @default.
• W350432274 cites W2105692968 @default.
• W350432274 cites W2145118081 @default.
• W350432274 cites W2177943720 @default.
• W350432274 doi "https://doi.org/10.1007/978-1-4615-1951-5_29" @default.
• W350432274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7668154" @default.
• W350432274 hasPublicationYear "1995" @default.
• W350432274 type Work @default.
• W350432274 sameAs 350432274 @default.
• W350432274 citedByCount "12" @default.
• W350432274 countsByYear W3504322742016 @default.
• W350432274 countsByYear W3504322742020 @default.
• W350432274 countsByYear W3504322742023 @default.
• W350432274 crossrefType "book-chapter" @default.
• W350432274 hasAuthorship W350432274A5051622981 @default.
• W350432274 hasConcept C126322002 @default.
• W350432274 hasConcept C13348194 @default.
• W350432274 hasConcept C134018914 @default.
• W350432274 hasConcept C159110408 @default.
• W350432274 hasConcept C170493617 @default.
• W350432274 hasConcept C17077164 @default.
• W350432274 hasConcept C185592680 @default.
• W350432274 hasConcept C203014093 @default.
• W350432274 hasConcept C2775944032 @default.
• W350432274 hasConcept C2776178377 @default.
• W350432274 hasConcept C2778750930 @default.
• W350432274 hasConcept C2781063702 @default.
• W350432274 hasConcept C2909179924 @default.
• W350432274 hasConcept C49453240 @default.
• W350432274 hasConcept C64943373 @default.
• W350432274 hasConcept C71924100 @default.
• W350432274 hasConcept C86803240 @default.
• W350432274 hasConceptScore W350432274C126322002 @default.
• W350432274 hasConceptScore W350432274C13348194 @default.
• W350432274 hasConceptScore W350432274C134018914 @default.
• W350432274 hasConceptScore W350432274C159110408 @default.
• W350432274 hasConceptScore W350432274C170493617 @default.
• W350432274 hasConceptScore W350432274C17077164 @default.
• W350432274 hasConceptScore W350432274C185592680 @default.
• W350432274 hasConceptScore W350432274C203014093 @default.
• W350432274 hasConceptScore W350432274C2775944032 @default.
• W350432274 hasConceptScore W350432274C2776178377 @default.
• W350432274 hasConceptScore W350432274C2778750930 @default.
• W350432274 hasConceptScore W350432274C2781063702 @default.
• W350432274 hasConceptScore W350432274C2909179924 @default.
• W350432274 hasConceptScore W350432274C49453240 @default.
• W350432274 hasConceptScore W350432274C64943373 @default.
• W350432274 hasConceptScore W350432274C71924100 @default.
• W350432274 hasConceptScore W350432274C86803240 @default.
• W350432274 hasLocation W3504322741 @default.
• W350432274 hasLocation W3504322742 @default.
• W350432274 hasOpenAccess W350432274 @default.
• W350432274 hasPrimaryLocation W3504322741 @default.
• W350432274 hasRelatedWork W1971852532 @default.
• W350432274 hasRelatedWork W1973483386 @default.
• W350432274 hasRelatedWork W1975735920 @default.
• W350432274 hasRelatedWork W2034583712 @default.
• W350432274 hasRelatedWork W2062004514 @default.
• W350432274 hasRelatedWork W2063619316 @default.
• W350432274 hasRelatedWork W2074821979 @default.
• W350432274 hasRelatedWork W2088121632 @default.
• W350432274 hasRelatedWork W2162607362 @default.
• W350432274 hasRelatedWork W4237202289 @default.
• W350432274 isParatext "false" @default.
• W350432274 isRetracted "false" @default.
• W350432274 magId "350432274" @default.

• next