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- W350959020 endingPage "2947" @default.
- W350959020 startingPage "2931" @default.
- W350959020 abstract "Protein homeostasis (proteostasis) is inextricably tied to cellular health and organismal lifespan. Aging, exposure to physiological and environmental stress, and expression of mutant and metastable proteins can cause an imbalance in the protein-folding landscape, which results in the formation of non-native protein aggregates that challenge the capacity of the proteostasis network (PN), increasing the risk for diseases associated with misfolding, aggregation, and aberrant regulation of cell stress responses. Molecular chaperones have central roles in each of the arms of the PN (protein synthesis, folding, disaggregation, and degradation), leading to the proposal that modulation of chaperone function could have therapeutic benefits for the large and growing family of diseases of protein conformation including neurodegeneration, metabolic diseases, and cancer. In this review, we will discuss the current strategies used to tune the PN through targeting molecular chaperones and assess the potential of the chemical biology of proteostasis." @default.
- W350959020 created "2016-06-24" @default.
- W350959020 creator A5004866198 @default.
- W350959020 creator A5083765269 @default.
- W350959020 date "2015-09-01" @default.
- W350959020 modified "2023-10-17" @default.
- W350959020 title "The Chemical Biology of Molecular Chaperones—Implications for Modulation of Proteostasis" @default.
- W350959020 cites W1532878531 @default.
- W350959020 cites W1541950149 @default.
- W350959020 cites W1552907768 @default.
- W350959020 cites W1554354855 @default.
- W350959020 cites W1570663378 @default.
- W350959020 cites W1586440254 @default.
- W350959020 cites W1588830049 @default.
- W350959020 cites W1602112219 @default.
- W350959020 cites W1760671874 @default.
- W350959020 cites W1835200336 @default.
- W350959020 cites W1864683138 @default.
- W350959020 cites W1892996896 @default.
- W350959020 cites W1952425797 @default.
- W350959020 cites W1955276614 @default.
- W350959020 cites W1964826325 @default.
- W350959020 cites W1965787931 @default.
- W350959020 cites W1965849506 @default.
- W350959020 cites W1967308926 @default.
- W350959020 cites W1968288262 @default.
- W350959020 cites W1968431321 @default.
- W350959020 cites W1968916175 @default.
- W350959020 cites W1970743470 @default.
- W350959020 cites W1971046207 @default.
- W350959020 cites W1972370905 @default.
- W350959020 cites W1974391976 @default.
- W350959020 cites W1975407164 @default.
- W350959020 cites W1977898751 @default.
- W350959020 cites W1978146959 @default.
- W350959020 cites W1978324338 @default.
- W350959020 cites W1979728079 @default.
- W350959020 cites W1980679718 @default.
- W350959020 cites W1981040109 @default.
- W350959020 cites W1981676889 @default.
- W350959020 cites W1982448065 @default.
- W350959020 cites W1983077689 @default.
- W350959020 cites W1983273078 @default.
- W350959020 cites W1984831405 @default.
- W350959020 cites W1985065867 @default.
- W350959020 cites W1987053877 @default.
- W350959020 cites W1987145868 @default.
- W350959020 cites W1988228513 @default.
- W350959020 cites W1988675578 @default.
- W350959020 cites W1991579889 @default.
- W350959020 cites W1992776376 @default.
- W350959020 cites W1997049152 @default.
- W350959020 cites W1997670933 @default.
- W350959020 cites W1998074678 @default.
- W350959020 cites W1998259550 @default.
- W350959020 cites W1999715990 @default.
- W350959020 cites W2000929246 @default.
- W350959020 cites W2001546169 @default.
- W350959020 cites W2001569984 @default.
- W350959020 cites W2001710697 @default.
- W350959020 cites W2002143632 @default.
- W350959020 cites W2002210017 @default.
- W350959020 cites W2002431899 @default.
- W350959020 cites W2004376767 @default.
- W350959020 cites W2004565109 @default.
- W350959020 cites W2005317701 @default.
- W350959020 cites W2005459694 @default.
- W350959020 cites W2007624219 @default.
- W350959020 cites W2008441315 @default.
- W350959020 cites W2009324686 @default.
- W350959020 cites W2009782661 @default.
- W350959020 cites W2010942421 @default.
- W350959020 cites W2012520981 @default.
- W350959020 cites W2013699930 @default.
- W350959020 cites W2013910899 @default.
- W350959020 cites W2013944211 @default.
- W350959020 cites W2016224818 @default.
- W350959020 cites W2016250665 @default.
- W350959020 cites W2018716591 @default.
- W350959020 cites W2018803778 @default.
- W350959020 cites W2019310505 @default.
- W350959020 cites W2022234086 @default.
- W350959020 cites W2022294369 @default.
- W350959020 cites W2022531767 @default.
- W350959020 cites W2025229617 @default.
- W350959020 cites W2025281252 @default.
- W350959020 cites W2026310024 @default.
- W350959020 cites W2028658556 @default.
- W350959020 cites W2029690888 @default.
- W350959020 cites W2030004872 @default.
- W350959020 cites W2032141646 @default.
- W350959020 cites W2032255930 @default.
- W350959020 cites W2032313009 @default.
- W350959020 cites W2032817175 @default.
- W350959020 cites W2036031534 @default.
- W350959020 cites W2036310769 @default.
- W350959020 cites W2039944716 @default.
- W350959020 cites W2040359453 @default.