Matches in SemOpenAlex for { <https://semopenalex.org/work/W35121938> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W35121938 abstract "Emerging evidence suggests that swine are a scientifically acceptable intermediate species (rodent-human) for conducting scientific research relevant to humans. The swine genome has recently been sequenced; but, a large-scale analysis of its content with respect to genes involved in nutrition or immunity has not been reported. To this end, a genome-based, analysis of model suitability of pig was conducted. This analysis revealed that familial gene expansion, driven mostly by immune-related genes, has occurred in pigs relative to humans at half the rate of mice to humans. Furthermore, pigs and humans have 3 fold less unique genes compared to mice. The number of pig-human restricted orthologs is 5 and 8 fold greater than the number of mouse-human or mouse-pig restricted orthologs respectively. Among shared orthologs, protein sequence homology is higher between human and pig compared to human and mice. Furthermore, protein functional domain preservation between human and pig is nearly twice that of mouse to human and pig to mouse. This large-scale comparative assessment of the pig, mouse and human genomes revealed an overwhelming similarity of swine to humans for most parameters. This work will contribute significantly toward using swine as models to promote both human and animal health particularly those with a nutritional and immunological component." @default.
- W35121938 created "2016-06-24" @default.
- W35121938 creator A5030498708 @default.
- W35121938 date "2013-04-01" @default.
- W35121938 modified "2023-09-25" @default.
- W35121938 title "Nutritional and Immunological Lessons Learned from the Porcine Genome" @default.
- W35121938 doi "https://doi.org/10.1096/fasebj.27.1_supplement.643.6" @default.
- W35121938 hasPublicationYear "2013" @default.
- W35121938 type Work @default.
- W35121938 sameAs 35121938 @default.
- W35121938 citedByCount "0" @default.
- W35121938 crossrefType "journal-article" @default.
- W35121938 hasAuthorship W35121938A5030498708 @default.
- W35121938 hasConcept C104317684 @default.
- W35121938 hasConcept C141231307 @default.
- W35121938 hasConcept C165525559 @default.
- W35121938 hasConcept C169899063 @default.
- W35121938 hasConcept C18903297 @default.
- W35121938 hasConcept C197077220 @default.
- W35121938 hasConcept C2778914748 @default.
- W35121938 hasConcept C2779341262 @default.
- W35121938 hasConcept C54355233 @default.
- W35121938 hasConcept C70721500 @default.
- W35121938 hasConcept C86803240 @default.
- W35121938 hasConcept C8891405 @default.
- W35121938 hasConceptScore W35121938C104317684 @default.
- W35121938 hasConceptScore W35121938C141231307 @default.
- W35121938 hasConceptScore W35121938C165525559 @default.
- W35121938 hasConceptScore W35121938C169899063 @default.
- W35121938 hasConceptScore W35121938C18903297 @default.
- W35121938 hasConceptScore W35121938C197077220 @default.
- W35121938 hasConceptScore W35121938C2778914748 @default.
- W35121938 hasConceptScore W35121938C2779341262 @default.
- W35121938 hasConceptScore W35121938C54355233 @default.
- W35121938 hasConceptScore W35121938C70721500 @default.
- W35121938 hasConceptScore W35121938C86803240 @default.
- W35121938 hasConceptScore W35121938C8891405 @default.
- W35121938 hasIssue "S1" @default.
- W35121938 hasLocation W351219381 @default.
- W35121938 hasOpenAccess W35121938 @default.
- W35121938 hasPrimaryLocation W351219381 @default.
- W35121938 hasRelatedWork W1442603624 @default.
- W35121938 hasRelatedWork W1603543036 @default.
- W35121938 hasRelatedWork W1991471459 @default.
- W35121938 hasRelatedWork W2045313050 @default.
- W35121938 hasRelatedWork W2064751958 @default.
- W35121938 hasRelatedWork W2066341288 @default.
- W35121938 hasRelatedWork W2074557265 @default.
- W35121938 hasRelatedWork W2376046968 @default.
- W35121938 hasRelatedWork W2086630149 @default.
- W35121938 hasRelatedWork W2094069166 @default.
- W35121938 hasVolume "27" @default.
- W35121938 isParatext "false" @default.
- W35121938 isRetracted "false" @default.
- W35121938 magId "35121938" @default.
- W35121938 workType "article" @default.