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• W35133280 abstract "Calcium (Ca2+) is the most universal carrier of biological signals: it modulates cell life from its origin at fertilization to its end in the apoptotic process. The signaling function of Ca2+ has had an unusual history. Discovered serendipitously at the end of the nineteenth century, it received almost no attention for decades. After its rediscovery in the 1960s, it grew in popularity and importance at an exponential pace. As progress advanced, it was recognized that the signaling function of Ca2+ had a number of unique properties. One is the ability of Ca2+ to act both as a first and as a second messenger. Ca2+ may recognize a canonical seven-transmembrane domain receptor at the external side of the plasma membrane, initiating an internal signaling cascade that may even involve Ca2+ itself. Another distinctive property of the Ca2+ signal is autoregulation. It occurs at the transcriptional and post-translational levels, as the expression and activity of a number of proteins involved in the transport of Ca2+ and in the processing of its signal are regulated by Ca2+ itself. Most importantly, the Ca2+ signal shows ambivalence. Cells need Ca2+ to correctly carry out most of their important functions. To this aim, they have developed a sophisticated array of means to carefully control its concentration and movements. But damage of various degrees, up to cell death, invariably follows the failure of the cell systems to properly control Ca2+." @default.
• W35133280 created "2016-06-24" @default.
• W35133280 creator A5010030643 @default.
• W35133280 date "2007-01-01" @default.
• W35133280 modified "2023-10-16" @default.
• W35133280 title "The unusual history and unique properties of the calcium signal" @default.
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• W35133280 doi "https://doi.org/10.1016/s0167-7306(06)41001-2" @default.
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