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- W3524043 abstract "1425 Objectives 11C-Raclopride is a Dopamine D2 receptor imaging agent, it has significant clinical application on early diagnostic of Parkinson Disease. Traditional synthesis method uses Desmethyl Raclopride Hydrobromide as precursor, and labels in NaOH/DMSO solvent. However, labeling yield is about 25%, this restricts routine clinical application. We attend to find a synthesis method with higher yield. Methods We used Desmethyl Raclopride without Hydrobromide as precursor, and employed K2CO3/Cs2CO3 to activate. GE TRACERlab FX C Pro was our synthesis platform. 11C-MeI was prepared by gas cycling method from 11C-CO2. 1mg Desmethyl Raclopride was solved in 0.5mL DMSO and 5mg dry K2CO3 was added, labeled by 11C-MeI in 85°C for 10 minutes, and then the mixture was diluted by 1ml H2O and separated by semi-preparation HPLC, using 20mM NaH2PO4 in 38% Ethanol/water solution as eluent. 11C-Raclopride was colleted in 15-20min and passed sterile filter. Results We achieve 40% yield by using new precursor and solvent, and radiochemical purity is above 99%. Conclusions Using non-Hydrobromide precursor and solvent without water can effectively improve synthesis yield of 11C-Raclopride. Research Support This study was sponsored by China Nature Science Fund (Number: 30770632)" @default.
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- W3524043 date "2011-05-01" @default.
- W3524043 modified "2023-09-27" @default.
- W3524043 title "A new synthesis method of 11C-Raclopride using non-hydrobromide precursor" @default.
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