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• W352744934 abstract "This chapter focuses on various animal models of giardiasis. Mice, rats, and gerbils are most commonly used in the development of laboratory models, although dogs, cats, rabbits, and sheep are also utilized. There have been numerous attempts to infect different strains of mice with isolates of G. duodenalis, but successful, reproducible infections can only be obtained in young animals, particularly neonates, suckling or weanling mice, although infections are of short duration. Alternatively, immunodeficient or immunocompromised animals can be used to prolong infections. Rats exhibit variable susceptibility to infection with different isolates of G. duodenalis, although success has been achieved with mature as well as immature animals. However, the gut transit time of rats is much slower than that of mice and more closely reflects the situation in humans. Consequently, the rat has been advocated as a more useful model host in studies on anti-giardial agents. The Mongolian gerbil (Meriones unguiculatus) is widely regarded as being the best experimental host of G. duodenalis infections to date and offers a much better alternative to mice as a laboratory model. They can be infected with isolates from a variety of hosts and are highly susceptible to infection with G. duodenalis- type organisms. Adult animals can be infected with either cysts or trophozoites cultured in vitro, and their prepatent time and pathogenesis are similar to those of the original hosts, and so permit pathological studies. No surgical procedures or anesthetics are required since parasites and drugs are administered orally, and no invasive procedures are involved in establishing experimental infections in this model." @default.
• W352744934 created "2016-06-24" @default.
• W352744934 creator A5086296060 @default.
• W352744934 date "1999-01-01" @default.
• W352744934 modified "2023-09-25" @default.
• W352744934 title "Animal Models of Giardiasis" @default.
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• W352744934 doi "https://doi.org/10.1016/b978-012775390-4/50242-6" @default.
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