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- W35359258 abstract "Cardiovascular complications in uremic patients are important factors influencing the mortality of patients undergoing long-term dialysis treatment. The accumulation in uremic circulation of uremic toxins or metabolites has been implicated for the development of atherosclerotic lesions in uremia. In this chapter, we focus on the carbonyl-amine chemistry in uremia, which results in two types of irreversible alterations of proteins: advanced glycation through the Maillard reaction and advanced lipoxidation derived from lipid peroxidation. We discuss chemistry of various reactive carbonyl compounds (RCOs) accumulating in the serum (“carbonyl stress”), their patho-biochemistry particularly in relation to cardiovascular complications and to peritoneal dysfunction and, finally, the contribution of nutrition to carbonyl stress." @default.
- W35359258 created "2016-06-24" @default.
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- W35359258 date "2013-01-01" @default.
- W35359258 modified "2023-09-23" @default.
- W35359258 title "Carbonyl Stress in Uremia" @default.
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- W35359258 doi "https://doi.org/10.1016/b978-0-12-391934-2.00007-2" @default.
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