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- W35472904 abstract "Acute alcohol (ethanol) exposure is linked with increased susceptibility to infection and increased mortality in trauma and burn patients. Dendritic cells (DCs) are central mediators in innate and adaptive immune responses, and play a role in presentation of pathogens to adaptive immune cells. We investigated the effects of acute ethanol exposure on bone marrow-derived dendritic cell (BM-DC) responses. Total bone marrow cells, obtained from 8-10wk old C57BL/6 male mice, were cultured in the presence of GM-CSF and IL-4 for 7 days. BM-DCs were harvested and treated with increasing doses of ethanol (50, 100 and 250 mM) at the time of, or 3 hours prior to, lipopolysaccharide (LPS). Following LPS, supernatants were collected for cytokine measurement and cells were harvested for flow cytometry. Concurrent acute ethanol exposure and LPS treatment resulted in a dose-dependent suppression of IL-6, IL-12p40, IL-23 and IL-10. Additionally, ethanol exposure prior to LPS, dysregulated the IL12p40/IL-23 balance and more profoundly suppressed IL-6 and IL-10 secretion by BMDCs, as compared with cells treated concurrently with ethanol and LPS. Ethanol treatment did not affect toll-like receptor (TLR)4 or TLR2 expression. In summary, our study demonstrates that acute ethanol exposure suppresses BM-DC LPS-induced responses irrespective of affecting TLR4 or TLR2 expression." @default.
- W35472904 created "2016-06-24" @default.
- W35472904 creator A5004201602 @default.
- W35472904 date "2013-01-01" @default.
- W35472904 modified "2023-09-26" @default.
- W35472904 title "Effects of Acute Alcohol Exposure on Post Burn Intestinal Immunity: Role of IL-23" @default.
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