Matches in SemOpenAlex for { <https://semopenalex.org/work/W354783951> ?p ?o ?g. }
- W354783951 abstract "SHP-1 is an SH2 domain-containing protein tyrosine phosphatase (PTP) implicated in the negative regulation of a diverse range of activatory signaling pathways in leukocytes. Structural studies have revealed that SHP-1 PTP activity is subject to direct inhibition by its amino terminal SH2 domain whereby autoinhibition is predicted to be relieved by a series of allosteric changes involving the sequential engagement of the carboxy and amino terminal SH2 domains of SHP-1 by phosphotyrosine-containing ligands. The major physiological ligands for SHP- 1 are a super-family of inhibitory receptors found in leukocytes that possess Immune receptor Tyrosine-based Inhibition Motifs (ITIMs) in their cytoplasmic domains which when tyrosine phosphorylated are capable of binding with high affinity to the SH2 domains of SHP-1. Hence, fully activated SHP-1 is localized to the plasma membrane. SHP-1 appears to mediate inhibition of the early steps of activatory signaling pathways but the mechanisms of SHP-1 action still remain to be elucidated." @default.
- W354783951 created "2016-06-24" @default.
- W354783951 creator A5034784794 @default.
- W354783951 creator A5056960672 @default.
- W354783951 date "2003-11-14" @default.
- W354783951 modified "2023-09-23" @default.
- W354783951 title "SHP-1 twelve years on: structure, ligands, substrates and biological roles" @default.
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