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- W355115564 abstract "This thesis details the discovery and development of several novel gold-catalysed reactions for the synthesis of nitrogen containing carbo- and heterocyclic frameworks from carbon-carbon triple bonds. The realisation of a 1,1-carboalkoxylation strategy to generate gold carbenes from ynamides is described. This novel skeletal rearrangement proceeds with a previously unreported nitrogen migration onto a gold carbene for the synthesis of highly functionalised indenes. The mechanism has been investigated using isotopic labelling which confirms the predicted mode of cyclisation, enforced by the electronic properties of ynamides. This work led to the discovery of a gold-catalysed polycyclisation reaction to generate complex three-dimensional tetracyclic products. The scope and limitations of this method are described, and the mechanism has been probed using isotopic labelling. A novel copper-catalysed cascade reaction has also been demonstrated towards the synthesis of valuable nitrogen heterocycles. Finally a gold-catalysed rearrangement of electron deficient alkynes under oxidative conditions is detailed along with the reaction optimisation and difficulties encountered." @default.
- W355115564 created "2016-06-24" @default.
- W355115564 creator A5061698165 @default.
- W355115564 date "2015-07-01" @default.
- W355115564 modified "2023-09-24" @default.
- W355115564 title "Novel transformations for the synthesis of nitrogen containing carbo- and heterocycles" @default.
- W355115564 hasPublicationYear "2015" @default.
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