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• W35566370 abstract "This chapter focuses on the role of parathyroid hormone-related peptide (PTHrP) signaling pathway in endochondral bone development and in adult skeletal homostasis. PTHrP was discovered as a mediator of hypercalcemia associated with malignancy, but is now known to be expressed by a large number of normal fetal and adult studies. The aminoterminal region of PTHrP reveals limited but significant homology with parathyroid hormone (PTH), resulting in the interaction of the first 34–36 residues of either the peptide with a single seven-transmembrane spanning G protein-linked receptor termed the PTH/PTHrP receptor, or the PTH-1 receptor. PTHrP plays a critical role in chondrocyte biology and in endochondral bone formation. Deficient PTHrP action in utero results in a distorted epiphyseal growth plate and marked skeletal deformity with ensuing neonatal death due to respiratory compromise. The complex processes resulting in normal endochondral bone development involve additional factors such as the hedgehog signaling pathway with which PTHrP interacts. PTHrP, like PTH, binds to receptors on cells of the ostoblast lineage, resulting in enhanced bone formation and also, indirectly, in augmented ostoclastic bone resorption. However, unlike PTH, which serves postnatally to defend against a decrease in extracellular calcium, endogenous PTHrP appears to play an important anabolic role in postnatal skeleton. Overall, these findings point to a critical role of PTHrP in normal skeletal development and in its maintenance. Further elucidation of the molecular role and interactions of PTHrP may therefore reveal new facets of the pathogenesis of a variety of metabolic bone diseases and potentially point to new directions for therapeutic interventions." @default.
• W35566370 created "2016-06-24" @default.
• W35566370 creator A5030199838 @default.
• W35566370 date "2006-01-01" @default.
• W35566370 modified "2023-09-25" @default.
• W35566370 title "Interaction of Parathyroid Hormone-related Peptide with the Skeleton" @default.
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• W35566370 doi "https://doi.org/10.1016/b978-012088562-6/50018-2" @default.
• W35566370 hasPublicationYear "2006" @default.
• W35566370 type Work @default.
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