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- W356446875 abstract "A jelen munkaban a PARP feherje szerepet vizsgaltuk a cukobetegseg szovődmenyeinek kialakulasaban. Kimutattuk, hogy az erek es a vese karosodasaban fontos szerepe van ennek a feherjenek, es a feherje aktivitasanak gatlasa allatokban javitja a betegseg lefolyasat. Osszefuggest talaltunk a PARP aktivacioja, valamint a rosszul beallitott cukorbetegseg kozott, es kimutattuk kulonfele sejten beluli szignal transzdukcios ut szerepet ezekben a folyamatokban. A munka szamos nemzetkozi szintű kozlemenyt eredmenyezett. | In the present project, we have investigated the role of the PARP enzyme in the pathogenesis of diabetic complications. We have demonstrated that the vascular and renal damage associated with diabetes is importantly mediated by the activation of the PARP enzyme. We have demonstrated a relationship between poorly controlled diabetes and the activation of PARP and we have demonstrated the role of several intracellular signal transduction pathways in the process. The work has resulted in a number of internationally significant publications." @default.
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- W356446875 date "2008-01-01" @default.
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- W356446875 title "A poli (ADP-ribóz) polimeráz enzim szerepe diabeteszes komplikációk patogenezisében = Poly (ADP-ribose) polymerase and diabetic complications" @default.
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