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• W35672600 abstract "The establishment of an optimum level of bone mineral during the years of growth, when modeling is superimposed on growth, is an important consideration in terms of lifelong skeletal integrity. Adult bone mineral status at any time in life is a function of the amount accumulated during the growing years and the amount lost during adult life. Since low bone mineral is associated with fracture risk 1 it is clear that bone mineral accrual during the growing years should be optimized, if possible. While peak bone mass is largely determined by heredity, which accounts for over 50% of the variance 2 , lifestyle patterns are also involved in a multifactorial state that is requisite for the maximization of bone mineral accrual during the growing years. Specifically, vigorous weight-bearing physical activity represents the best possibility for enhancing the attainment of an optimal level of bone mineral, within genetic limits 3 . The potential of weight-bearing physical activity to positively influence bone mineral acquisition during the growing years is a subject of increasing interest. Numerous studies have appeared in the literature over the past few years dealing with this topic. Although there has been some degree of inconsistency in the results of these studies, the available evidence suggests a significant and positive relationship between physical activity and bone mineral accrual during the growing years. Some of the inconsistent results can be attributed to limitations in study design. These include small numbers of subjects, a short duration of intervention and the difficulty in accurately assessing normal physical activity patterns in children and adolescents. But by far the greatest problem has to do with the failure to control for the wide range in maturational status for children of the same chronological age. The uneven spread in maturity status in children of the same age creates one of the most difficult challenges facing researchers studying adolescent bone growth." @default.
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• W35672600 date "2003-12-01" @default.
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• W35672600 title "Bone growth and exercise studies: The complications of maturation." @default.
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