FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W357278364> ?p ?o ?g. }

• W357278364 endingPage "405" @default.
• W357278364 startingPage "395" @default.
• W357278364 abstract "Nowadays, stem cells have been introduced as an appropriate source of regenerative medicine for treatment of type I diabetes. Human umbilical cord matrix-derived mesenchymal cells (hUCMC) have successfully been differentiated into insulin producing cells. The isolated hUCM cells were characterized by the expression of stem cell surface markers and by differentiation into adipocytes and osteocytes. The hUCMCs were cultured with different concentrations of neural conditional medium (NCM) and were induced to differentiate into insulin producing cells (IPCs). As 60% NCM concentration resulted in higher nestin and PDX1 expression, the cells were first exposed to 60% NCM and were then induced for IPCs differentiation. PDX1 and insulin gene expression was evaluated in the treated cells. Also, the secretion capacity of the IPCs was assessed by glucose challenge test. IPCs were transferred under the rat kidney capsule. Blood glucose level, weight gain and immunohistochemistry assessments were done in the treated animals. hUCMC expressed mesenchymal cell surface markers and successfully differentiated into adipocytes and osteocytes. Higher NCM concentration resulted in higher PDX1 and nestin expression. The IPCs expressed insulin and PDX1. IPCs were detectable under the kidney capsule 2 months after injection. IPCs transplantation resulted in a sharp decline of blood sugar level and less weight loss. Differentiated hUCM cells could alleviate the insulin deprivation in the rat model of type I diabetes. In addition, higher NCM concentration leads to more differentiation into IPCs and more nestin and PDX1 expression. Kidney capsule can serve as a suitable nominee for IPCs transplantation." @default.
• W357278364 created "2016-06-24" @default.
• W357278364 creator A5007922162 @default.
• W357278364 creator A5018294970 @default.
• W357278364 creator A5069535662 @default.
• W357278364 creator A5069920343 @default.
• W357278364 creator A5082242813 @default.
• W357278364 date "2015-08-01" @default.
• W357278364 modified "2023-10-17" @default.
• W357278364 title "Transplantation of differentiated umbilical cord mesenchymal cells under kidney capsule for control of type I diabetes in rat" @default.
• W357278364 cites W1518560201 @default.
• W357278364 cites W1911808314 @default.
• W357278364 cites W1965446527 @default.
• W357278364 cites W1969644104 @default.
• W357278364 cites W1972187787 @default.
• W357278364 cites W1975503903 @default.
• W357278364 cites W1993996055 @default.
• W357278364 cites W2003528130 @default.
• W357278364 cites W2007269864 @default.
• W357278364 cites W2007293466 @default.
• W357278364 cites W2017655712 @default.
• W357278364 cites W2017968279 @default.
• W357278364 cites W2020267609 @default.
• W357278364 cites W2026641491 @default.
• W357278364 cites W2031743699 @default.
• W357278364 cites W2037134742 @default.
• W357278364 cites W2038818919 @default.
• W357278364 cites W2046095052 @default.
• W357278364 cites W2048438191 @default.
• W357278364 cites W2056510698 @default.
• W357278364 cites W2063727958 @default.
• W357278364 cites W2067365513 @default.
• W357278364 cites W2068665887 @default.
• W357278364 cites W2071218401 @default.
• W357278364 cites W2076770967 @default.
• W357278364 cites W2084544351 @default.
• W357278364 cites W2123436766 @default.
• W357278364 cites W2129536482 @default.
• W357278364 cites W2134760433 @default.
• W357278364 cites W2137315507 @default.
• W357278364 cites W2137987484 @default.
• W357278364 cites W2139167033 @default.
• W357278364 cites W2144283470 @default.
• W357278364 cites W2152841620 @default.
• W357278364 cites W2158369920 @default.
• W357278364 cites W2168800437 @default.
• W357278364 cites W2169191544 @default.
• W357278364 cites W2172051122 @default.
• W357278364 doi "https://doi.org/10.1016/j.tice.2015.04.008" @default.
• W357278364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26025422" @default.
• W357278364 hasPublicationYear "2015" @default.
• W357278364 type Work @default.
• W357278364 sameAs 357278364 @default.
• W357278364 citedByCount "6" @default.
• W357278364 countsByYear W3572783642016 @default.
• W357278364 countsByYear W3572783642017 @default.
• W357278364 countsByYear W3572783642019 @default.
• W357278364 countsByYear W3572783642020 @default.
• W357278364 crossrefType "journal-article" @default.
• W357278364 hasAuthorship W357278364A5007922162 @default.
• W357278364 hasAuthorship W357278364A5018294970 @default.
• W357278364 hasAuthorship W357278364A5069535662 @default.
• W357278364 hasAuthorship W357278364A5069920343 @default.
• W357278364 hasAuthorship W357278364A5082242813 @default.
• W357278364 hasConcept C119577978 @default.
• W357278364 hasConcept C126322002 @default.
• W357278364 hasConcept C134018914 @default.
• W357278364 hasConcept C136834591 @default.
• W357278364 hasConcept C165220095 @default.
• W357278364 hasConcept C198826908 @default.
• W357278364 hasConcept C203014093 @default.
• W357278364 hasConcept C2776955114 @default.
• W357278364 hasConcept C2777738006 @default.
• W357278364 hasConcept C2778881546 @default.
• W357278364 hasConcept C2779050171 @default.
• W357278364 hasConcept C2779306644 @default.
• W357278364 hasConcept C2780091579 @default.
• W357278364 hasConcept C28328180 @default.
• W357278364 hasConcept C2911091166 @default.
• W357278364 hasConcept C71924100 @default.
• W357278364 hasConcept C86803240 @default.
• W357278364 hasConcept C95444343 @default.
• W357278364 hasConceptScore W357278364C119577978 @default.
• W357278364 hasConceptScore W357278364C126322002 @default.
• W357278364 hasConceptScore W357278364C134018914 @default.
• W357278364 hasConceptScore W357278364C136834591 @default.
• W357278364 hasConceptScore W357278364C165220095 @default.
• W357278364 hasConceptScore W357278364C198826908 @default.
• W357278364 hasConceptScore W357278364C203014093 @default.
• W357278364 hasConceptScore W357278364C2776955114 @default.
• W357278364 hasConceptScore W357278364C2777738006 @default.
• W357278364 hasConceptScore W357278364C2778881546 @default.
• W357278364 hasConceptScore W357278364C2779050171 @default.
• W357278364 hasConceptScore W357278364C2779306644 @default.
• W357278364 hasConceptScore W357278364C2780091579 @default.
• W357278364 hasConceptScore W357278364C28328180 @default.
• W357278364 hasConceptScore W357278364C2911091166 @default.
• W357278364 hasConceptScore W357278364C71924100 @default.

• next