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• W3574144 abstract "Publisher Summary This chapter discusses that peptide hormones are synthesized in a larger precursor form that find its way into the circulation. Metabolic fragments of the usual biologically active form of the hormone are detected in circulation with some antisera. Where precursor or fragment molecules represent a significant fraction of hormone, the interpretation of hormonal concentrations, whether measured by bioassay or radioimmunoassay, is more complicated than when a single hormonal form predominates. Studies reveal that many peptide hormones are found in more than one form in plasma and in glandular and other tissue extracts. These forms may or may not have biological activity and may represent either precursor or metabolic product of the well-known, well-characterized, biologically active hormone. These observations of heterogeneity have introduced complications into the interpretation of hormonal concentrations as measured by radioimmunoassay." @default.
• W3574144 created "2016-06-24" @default.
• W3574144 creator A5011477589 @default.
• W3574144 date "1974-01-01" @default.
• W3574144 modified "2023-09-23" @default.
• W3574144 title "Heterogeneity of Peptide Hormones" @default.
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• W3574144 doi "https://doi.org/10.1016/b978-0-12-571130-2.50020-1" @default.
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