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- W35756087 abstract "Abstract The prevalence of allergic diseases, such as asthma, has significantly increased in Western society over the past 30 years. One explanation for this trend is embodied by the hygiene hypothesis, which suggests that decreased microbial exposure may lead to an increased risk of allergic disease. Consistent with this notion, colonization with the common commensal bacteria Bacteroides fragilis or treatment with its purified capsular polysaccharide (PSA) can induce a regulatory population capable of suppressing effector T cell function in vitro and in vivo, including EAE and IBD disease models. Our previous findings revealed a dramatic increase in CD4+CD25+CD45Rblow cells upon stimulation with PSA, and these cells were able to suppress T cell activation in an IL-10 dependent fashion. Here we show that oral treatment of C57Bl/6 mice with PSA generates a FoxP3- population of cells within the spleen, and that these cells are capable of suppressing asthmatic lung inflammation. This activity was given to naïve recipients by the adoptive transfer of CD4+ splenocytes from PSA-treated mice. In contrast to previous data, transferred T cells from IL-10-deficient mice were also able to protect naïve recipients from asthma, ultimately revealing a novel mechanism by which commensal antigen-induced memory T cells influence the peripheral immune system to decrease susceptibility to allergic inflammation." @default.
- W35756087 created "2016-06-24" @default.
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- W35756087 date "2013-05-01" @default.
- W35756087 modified "2023-10-16" @default.
- W35756087 title "Bacterial polysaccharide exposure limits asthmatic inflammation. (P6051)" @default.
- W35756087 doi "https://doi.org/10.4049/jimmunol.190.supp.120.26" @default.
- W35756087 hasPublicationYear "2013" @default.
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